Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice

Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice

Nonalcoholic fatty liver disease (NAFLD) is increasingly common among patients with type 2 diabetes mellitus (T2DM). The two conditions can act synergistically to produce adverse outcomes. However, the therapeutic options for patients with NAFLD and T2DM are currently limited. Human umbilical cord-d...

Full description

Saved in:

Bibliographic Details
Main Authors:	Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu
Format:	Article
Language:	English
Published:	Wiley 2019-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2019/8628027
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice
by: Jing Xue, et al.
Published: (2020-01-01)

Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages
by: Yanxia Fu, et al.
Published: (2022-01-01)

Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure
by: Yunxia Tang, et al.
Published: (2016-01-01)

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
by: E. Russo, et al.
Published: (2022-01-01)

Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
by: Irina Arutyunyan, et al.
Published: (2016-01-01)

Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy
by: Liming Wang, et al.
Published: (2016-01-01)

Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice
by: Weifeng Gu, et al.
Published: (2025-01-01)

Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhanced Proangiogenic Potential of Cardiac Fibroblasts via Angiopoietin-Like 4
by: Jiejie Li, et al.
Published: (2022-01-01)

Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells
by: Li Guo, et al.
Published: (2017-01-01)

Urothelial Differentiation of Human Umbilical Cord-Derived Mesenchymal Stromal Cells In Vitro
by: Shuai Wu, et al.
Published: (2013-01-01)

Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration
by: Lingling E, et al.
Published: (2021-01-01)

GLP-1 Gene-Modified Human Umbilical Cord Mesenchymal Stem Cell Line Improves Blood Glucose Level in Type 2 Diabetic Mice
by: Ying Chang, et al.
Published: (2019-01-01)

Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis
by: GONG Jin, et al.
Published: (2025-01-01)

Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats
by: Jiawei Wang, et al.
Published: (2021-01-01)

Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions
by: Yong-Jik Lee, et al.
Published: (2017-01-01)

Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats
by: Suja Rani Sasidharan, et al.
Published: (2014-01-01)

Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats
by: Yongting Zhang, et al.
Published: (2018-01-01)

Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study
by: Chunran Xue, et al.
Published: (2025-02-01)

Gamisoyo-San Ameliorates Neuroinflammation in the Spinal Cord of hSOD1G93A Transgenic Mice
by: MuDan Cai, et al.
Published: (2018-01-01)

Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine
by: Tania Sultana, et al.
Published: (2018-01-01)

Cryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis
by: Bo Yan, et al.
Published: (2025-01-01)

Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews
by: Cunping Yin, et al.
Published: (2016-01-01)

Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A
by: Mingliang Zhang, et al.
Published: (2021-01-01)

Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II
by: Yuhe Jiang, et al.
Published: (2025-01-01)

Evaluation of Tissue Homogenization to Support the Generation of GMP-Compliant Mesenchymal Stromal Cells from the Umbilical Cord
by: Ryan J. Emnett, et al.
Published: (2016-01-01)

Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue
by: Jin-Hee Kim, et al.
Published: (2018-01-01)

Manufacturing of Human Umbilical Cord Mesenchymal Stromal Cells on Microcarriers in a Dynamic System for Clinical Use
by: Florian Petry, et al.
Published: (2016-01-01)

Current Treatment Options for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
by: Melanie D Beaton
Published: (2012-01-01)

Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity
by: Mona Karem Amin, et al.
Published: (2022-01-01)

Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents
by: Lian Tock, et al.
Published: (2010-01-01)

Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice
by: Gilles Willemin, et al.
Published: (2013-01-01)

Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis
by: Eric Priyo Prasetyo, et al.
Published: (2025-01-01)

Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Skin Matrix Synthesis and Pigmentation
by: Kee LT, et al.
Published: (2025-02-01)

Calcium Chloride vs. Mechanical Preparation of Fibrinogen-Depleted Human Platelet Lysate: Implications for Umbilical Cord Mesenchymal Stem Cell Culture
by: Yen Theng Lim, et al.
Published: (2024-12-01)

Suspected Nonalcoholic Fatty Liver Disease Is Not Associated with Vitamin D Status in Adolescents after Adjustment for Obesity
by: Karin Katz, et al.
Published: (2010-01-01)

Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells
by: Qi-Ming Huang, et al.
Published: (2024-12-01)

Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation
by: Qiongqiong Gao, et al.
Published: (2023-01-01)

Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord–Derived Mesenchymal Stem Cell–Mediated Rheumatoid Arthritis Therapy
by: Guangyang Liu, et al.
Published: (2025-01-01)

Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease
by: Gene P. Ables
Published: (2012-01-01)

Nonalcoholic Fatty Hepatitis: An Important Clinical Condition
by: Samuel W. French, et al.
Published: (1989-01-01)