Treatment of Bullous Systemic Lupus Erythematosus
Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/167064 |
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| author | Lihua Duan Liying Chen Shan Zhong Ying Wang Yan Huang Yan He Jie Chen Guixiu Shi |
| author_facet | Lihua Duan Liying Chen Shan Zhong Ying Wang Yan Huang Yan He Jie Chen Guixiu Shi |
| author_sort | Lihua Duan |
| collection | DOAJ |
| description | Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlying erythematous edematous plaques. Skin biopsy from BSLE patients shows subepidermal bullae with numerous neutrophils and only occasional eosinophils. Furthermore, immunofluorescence examination showed linear deposition of lgG, lgA, C3, and C1q along the basement membrane zone. BSLE patients with corticosteroids treatment constantly do not receive a marked improvement, while dapsone generally dramatically improved the skin condition. Recently, it has been reported that quite a few cases of BSLE were successfully treated with other immune suppressive drugs. Therefore, a comprehensive review of the treatment of BSLE would be beneficial to cure the disease. |
| format | Article |
| id | doaj-art-c7f497a5de9d459ab2d3d31105d4f51a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c7f497a5de9d459ab2d3d31105d4f51a2025-02-03T05:48:26ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/167064167064Treatment of Bullous Systemic Lupus ErythematosusLihua Duan0Liying Chen1Shan Zhong2Ying Wang3Yan Huang4Yan He5Jie Chen6Guixiu Shi7Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Pathology, The First Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Immunology, College of Medicine, Xiamen University, Xiamen 361102, ChinaDepartment of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, ChinaBullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlying erythematous edematous plaques. Skin biopsy from BSLE patients shows subepidermal bullae with numerous neutrophils and only occasional eosinophils. Furthermore, immunofluorescence examination showed linear deposition of lgG, lgA, C3, and C1q along the basement membrane zone. BSLE patients with corticosteroids treatment constantly do not receive a marked improvement, while dapsone generally dramatically improved the skin condition. Recently, it has been reported that quite a few cases of BSLE were successfully treated with other immune suppressive drugs. Therefore, a comprehensive review of the treatment of BSLE would be beneficial to cure the disease.http://dx.doi.org/10.1155/2015/167064 |
| spellingShingle | Lihua Duan Liying Chen Shan Zhong Ying Wang Yan Huang Yan He Jie Chen Guixiu Shi Treatment of Bullous Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Treatment of Bullous Systemic Lupus Erythematosus |
| title_full | Treatment of Bullous Systemic Lupus Erythematosus |
| title_fullStr | Treatment of Bullous Systemic Lupus Erythematosus |
| title_full_unstemmed | Treatment of Bullous Systemic Lupus Erythematosus |
| title_short | Treatment of Bullous Systemic Lupus Erythematosus |
| title_sort | treatment of bullous systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2015/167064 |
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