CRLF2-rearranged B-cell ALL with extramedullary lineage switch to AML following CD19-targeted therapy

CRLF2-rearranged B-cell ALL with extramedullary lineage switch to AML following CD19-targeted therapy

Lineage switch (LS) refers to the immunophenotypic transformation of one leukemia lineage to another (ie, lymphoid to myeloid) with retention of baseline genetics. This phenomenon was originally observed in infants with B-lymphoblastic leukemia (B-ALL) with KMT2A rearrangements following chemotherap...

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Main Authors: Nisha Patel, Adam Lamble, Ilan Kirsch, Haneen Shalabi, Hao-Wei Wang, Sara K. Silbert, Samantha Scanlon, Constance M Yuan, Alyssa Doverte, Jake Wellek, Raul Braylan, Mark Ahlman, Evrim B Turkbey, Sandra D Bohling, Karen M Chisholm, Murat Alp Oztek, Mike LaLoggia, Anupam Verma, Alexandra E Kovach, Brent L Wood, Kasey Leger, Nirali N. Shah
Format: Article
Language:English
Published: BMJ Publishing Group 2024-10-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/10/e009499.full
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