Meta-analysis of multi-center transcriptomic profiles and machine learning reveal phospholipase Cβ4 as a Wnt/Ca²+ signaling mediator in glioblastoma immunotherapy

Meta-analysis of multi-center transcriptomic profiles and machine learning reveal phospholipase Cβ4 as a Wnt/Ca²+ signaling mediator in glioblastoma immunotherapy

IntroductionGlioblastoma (GBM) is a highly aggressive brain tumor characterized by pronounced invasiveness, rapid progression, frequent recurrence, and poor clinical prognosis. Current treatment strategies remain inadequate due to the lack of effective molecular targets, underscoring the urgent need...

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Bibliographic Details
Main Authors: Zhaoming Song, Fei Wang, Chen Yang, Yanao Guo, Jinfeng Li, Run Huang, Hongyi Ling, Guosheng Cheng, Zhouqing Chen, Zhanchi Zhu, Zhong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
glioblastoma
PLCB4
machine learning
tumor microenvironment
multi-omics
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610683/full
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