Retrospective Study of Salinomycin Toxicosis in 66 Cats
We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2010/147142 |
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| author | Akos Pakozdy Iris Challande-Kathman Marcus Doherr Sigitas Cizinauskas Simon J. Wheeler Anna Oevermann Andre Jaggy |
| author_facet | Akos Pakozdy Iris Challande-Kathman Marcus Doherr Sigitas Cizinauskas Simon J. Wheeler Anna Oevermann Andre Jaggy |
| author_sort | Akos Pakozdy |
| collection | DOAJ |
| description | We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery. |
| format | Article |
| id | doaj-art-c7d963094f844d92b90a81dfef58edd4 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-c7d963094f844d92b90a81dfef58edd42025-02-03T06:13:16ZengWileyVeterinary Medicine International2042-00482010-01-01201010.4061/2010/147142147142Retrospective Study of Salinomycin Toxicosis in 66 CatsAkos Pakozdy0Iris Challande-Kathman1Marcus Doherr2Sigitas Cizinauskas3Simon J. Wheeler4Anna Oevermann5Andre Jaggy6Department for Companion Animals and Horses, Small Animal Clinic, University of Veterinary Medicine Vienna, 1210 Vienna, Veterinaerplatz 1, AustriaDivision of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, SwitzerlandDivision of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, SwitzerlandSmall Animal Hospital AISTI, Vantaa, FinlandDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USADivision of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, SwitzerlandDivision of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, SwitzerlandWe examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery.http://dx.doi.org/10.4061/2010/147142 |
| spellingShingle | Akos Pakozdy Iris Challande-Kathman Marcus Doherr Sigitas Cizinauskas Simon J. Wheeler Anna Oevermann Andre Jaggy Retrospective Study of Salinomycin Toxicosis in 66 Cats Veterinary Medicine International |
| title | Retrospective Study of Salinomycin Toxicosis in 66 Cats |
| title_full | Retrospective Study of Salinomycin Toxicosis in 66 Cats |
| title_fullStr | Retrospective Study of Salinomycin Toxicosis in 66 Cats |
| title_full_unstemmed | Retrospective Study of Salinomycin Toxicosis in 66 Cats |
| title_short | Retrospective Study of Salinomycin Toxicosis in 66 Cats |
| title_sort | retrospective study of salinomycin toxicosis in 66 cats |
| url | http://dx.doi.org/10.4061/2010/147142 |
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