A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS)

A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS)

Vaccine immunogenicity is affected by a variety of factors. Melatonin has been reported to affect immune responses to vaccines and infection. This was a randomized open-label trial – in which adults scheduled to receive the influenza vaccine were randomized to 5 mg melatonin or control to evaluate t...

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Main Authors: Rachel U. Lee, Nora L. Watson, Gena L. Glickman, Lindsey White, Sandra D. Isidean, Chad K. Porter, Monique Hollis-Perry, Samuel R. Walther, Santina Maiolatesi, Martha Sedegah, Harini Ganeshan, Jun Huang, David A. Boulifard, Daniel Ewing, Appavu K. Sundaram, Elizabeth M. Harrison, Katherine DeTizio, Maria Belmonte, Arnel Belmonte, Sandra Inoue, Alexandra Easterling, Elizabeth S. Cooper, Janine Danko
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Vaccine immunogenicity
influenza vaccine
melatonin
vaccine adjuvant
humoral immunity
cellular immunity
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2419742
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