Marchiafava–Bignami Disease Associated with Spinal Involvement
Marchiafava–Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a hi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/8867383 |
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| author | Jhon Perea María Belén Luis Luciana Grimanesa Lázaro Sergio Scollo Agustina Tamargo José Crespo Maira Avalle Horacio Solarz Nora Fernández Liguori Ricardo Alonso |
| author_facet | Jhon Perea María Belén Luis Luciana Grimanesa Lázaro Sergio Scollo Agustina Tamargo José Crespo Maira Avalle Horacio Solarz Nora Fernández Liguori Ricardo Alonso |
| author_sort | Jhon Perea |
| collection | DOAJ |
| description | Marchiafava–Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a history of alcoholism or known malabsorption disease, who presented with altered consciousness and neurologic impairment. Complex B deficiency was addressed. Magnetic resonance imaging (MRI) showed typical corpus callosum lesions. The clinical features and radiologic images suggested spinal cord involvement. Brain histopathologic findings were consistent with MBD. Despite vitamin replacement therapy, he had a poor outcome. |
| format | Article |
| id | doaj-art-c7ba6d938409414ca34f27428f4c03fc |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-c7ba6d938409414ca34f27428f4c03fc2025-02-03T01:00:12ZengWileyCase Reports in Neurological Medicine2090-66682090-66762020-01-01202010.1155/2020/88673838867383Marchiafava–Bignami Disease Associated with Spinal InvolvementJhon Perea0María Belén Luis1Luciana Grimanesa Lázaro2Sergio Scollo3Agustina Tamargo4José Crespo5Maira Avalle6Horacio Solarz7Nora Fernández Liguori8Ricardo Alonso9Department of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaAnatomical Pathology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaDepartment of Neurology, Sanatorio Güemes—University Hospital, Buenos Aires, ArgentinaMarchiafava–Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a history of alcoholism or known malabsorption disease, who presented with altered consciousness and neurologic impairment. Complex B deficiency was addressed. Magnetic resonance imaging (MRI) showed typical corpus callosum lesions. The clinical features and radiologic images suggested spinal cord involvement. Brain histopathologic findings were consistent with MBD. Despite vitamin replacement therapy, he had a poor outcome.http://dx.doi.org/10.1155/2020/8867383 |
| spellingShingle | Jhon Perea María Belén Luis Luciana Grimanesa Lázaro Sergio Scollo Agustina Tamargo José Crespo Maira Avalle Horacio Solarz Nora Fernández Liguori Ricardo Alonso Marchiafava–Bignami Disease Associated with Spinal Involvement Case Reports in Neurological Medicine |
| title | Marchiafava–Bignami Disease Associated with Spinal Involvement |
| title_full | Marchiafava–Bignami Disease Associated with Spinal Involvement |
| title_fullStr | Marchiafava–Bignami Disease Associated with Spinal Involvement |
| title_full_unstemmed | Marchiafava–Bignami Disease Associated with Spinal Involvement |
| title_short | Marchiafava–Bignami Disease Associated with Spinal Involvement |
| title_sort | marchiafava bignami disease associated with spinal involvement |
| url | http://dx.doi.org/10.1155/2020/8867383 |
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