Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.

Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.

Dengue virus (DENV) is a public health challenge across the tropics and subtropics. Currently, there is no licensed prophylactic or antiviral treatment for dengue. The novel DENV inhibitor JNJ-1802 can significantly reduce viral load in mice and non-human primates. Here, using a mechanistic viral ki...

Full description

Saved in:
Bibliographic Details
Main Authors: Clare P McCormack, Olivia Goethals, Nele Goeyvaerts, Xavier D Woot de Trixhe, Peggy Geluykens, Doortje Borrenberghs, Neil M Ferguson, Oliver Ackaert, Ilaria Dorigatti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011662&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items