Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling

Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling

Abstract The transcriptional repressor FOXN3 plays a key role in regulating pulmonary inflammatory responses, which are crucial in the development of pulmonary fibrosis. However, its specific regulatory function in lung fibrosis remains unclear. Here, we show that FOXN3 suppresses pulmonary fibrosis...

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Main Authors: Jinjin Yu, Yingke Li, Yiming Li, Xiaotian Liu, Qingyang Huo, Nan Wu, Yangxia Zhang, Taoling Zeng, Yong Zhang, Henry You Li, Jie Lian, Jihong Zhou, Emmanuel Jairaj Moses, Jian Geng, Juntang Lin, Wei Li, Xinxing Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56922-7
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