Pro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis?

Pro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis?

Cardiac fibrosis is a major driver of heart failure, a leading cause of morbidity and mortality worldwide. Advances in single-cell transcriptomics have revealed the pivotal role of SPP1+ macrophages in the pathogenesis of cardiac fibrosis, positioning them as critical mediators and promising therape...

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Bibliographic Details
Main Authors: Moritz Uhlig, Sebastian Billig, Jan Wienhold, David Schumacher
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
fibrosis
macrophages
cardiac fibrosis
organ fibrosis
Spp1
Trem2
Online Access:https://www.mdpi.com/2073-4409/14/5/345
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