Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing
Abstract The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production of endogenous nitric oxide (NO) due to the hypergl...
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03135-1 |
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| author | Dan Xia Ying Guo Ruodan Xu Ning Li |
| author_facet | Dan Xia Ying Guo Ruodan Xu Ning Li |
| author_sort | Dan Xia |
| collection | DOAJ |
| description | Abstract The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production of endogenous nitric oxide (NO) due to the hyperglycemic microenvironment typical of chronic diabetes. While both endogenous and exogenous NO have been shown to promote the healing process of diabetic wounds, the direct application of NO in wound management is limited due to its gaseous nature and the risk of explosive release. This review summarizes recent advances of nanodressings incorporating NO donors in the treatment of diabetic wounds, detailing the specific conditions under which these nanodressings facilitate NO release, with a focus on the beneficial effects of NO, strategies for its supplementation, and the challenges encountered in the clinical translation of NO donors as a clinically viable nanomedicine in the context of improving diabetic wound healing. Graphical Abstract |
| format | Article |
| id | doaj-art-c7918899bfba4dd08b3751c08b82e32c |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-c7918899bfba4dd08b3751c08b82e32c2025-02-02T12:41:08ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112410.1186/s12951-025-03135-1Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healingDan Xia0Ying Guo1Ruodan Xu2Ning Li3Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of TechnologyTianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of TechnologyDepartment of Biobmedical Engineering and Technology, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical SciencesDepartment of Biobmedical Engineering and Technology, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical SciencesAbstract The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production of endogenous nitric oxide (NO) due to the hyperglycemic microenvironment typical of chronic diabetes. While both endogenous and exogenous NO have been shown to promote the healing process of diabetic wounds, the direct application of NO in wound management is limited due to its gaseous nature and the risk of explosive release. This review summarizes recent advances of nanodressings incorporating NO donors in the treatment of diabetic wounds, detailing the specific conditions under which these nanodressings facilitate NO release, with a focus on the beneficial effects of NO, strategies for its supplementation, and the challenges encountered in the clinical translation of NO donors as a clinically viable nanomedicine in the context of improving diabetic wound healing. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03135-1Nitric oxideDiabetic wound healingNanodressing |
| spellingShingle | Dan Xia Ying Guo Ruodan Xu Ning Li Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing Journal of Nanobiotechnology Nitric oxide Diabetic wound healing Nanodressing |
| title | Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing |
| title_full | Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing |
| title_fullStr | Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing |
| title_full_unstemmed | Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing |
| title_short | Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing |
| title_sort | emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing |
| topic | Nitric oxide Diabetic wound healing Nanodressing |
| url | https://doi.org/10.1186/s12951-025-03135-1 |
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