Single-nucleus RNA sequencing defines adipose tissue subpopulations that contribute to Tibetan pig cold adaptation

Single-nucleus RNA sequencing defines adipose tissue subpopulations that contribute to Tibetan pig cold adaptation

Abstract Background Thermogenic beige adipocyte displays a remarkable ability in mammals to adapt to cold environments, but the underlying cellular mechanisms remain unclear, especially in pigs that lack functional UCP1. Results Multilocular beige adipocytes were observed in both Tibetan pigs (cold-...

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Main Authors: Jiali Liu, Yao Jiang, Tianxia Liu, Chuanhe Chen, Linya Chui, Along Cui, Xueping Zhang, Xiao Wang, Yu Wang, Chunhuai Yang, Ying Zhang, Tianwen Wu, Shulin Yang, Jiaojiao Huang, Cong Tao, Jianguo Zhao, Yanfang Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Biology
Subjects:
Pig
snRNA-seq
Adipocytes
Subpopulations
Cold stimulation
Online Access:https://doi.org/10.1186/s12915-025-02211-0
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