Elotuzumab for Treatment of Multiple Myeloma (Literature Review)
Chemotherapy has been the main treatment option for multiple myeloma for several decades. However, a considerable increase in the life expectancy was observed in multiple myeloma patients when thalidomide, bortezomib and lenalidomide had been introduced into clinical practice. Nevertheless, the dise...
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| Format: | Article |
| Language: | Russian |
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Practical Medicine Publishing House
2016-10-01
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| Series: | Клиническая онкогематология |
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| Online Access: | http://bloodjournal.ru/en/elotuzumab-for-treatment-of-multiple-myeloma-literature-review/ |
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| _version_ | 1849685853020880896 |
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| author | OM Votyakova |
| author_facet | OM Votyakova |
| author_sort | OM Votyakova |
| collection | DOAJ |
| description | Chemotherapy has been the main treatment option for multiple myeloma for several decades. However, a considerable increase in the life expectancy was observed in multiple myeloma patients when thalidomide, bortezomib and lenalidomide had been introduced into clinical practice. Nevertheless, the disease remains incurable and there is an unmet need in fundamentally new treatment methods. Elotuzumab is a humanized IgG1 monoclonal antibody that specifically targets SLAMF7, an antigen belonging to the signaling lymphocytic activation molecule family, with its high expression detected on myeloma cells. This review presents the mechanism of action of elotuzumab, preclinical data and the main clinical studies of this monoclonal antibody. |
| format | Article |
| id | doaj-art-c78ac88cbb084e2987635e6a0503a6cb |
| institution | DOAJ |
| issn | 1997-6933 2500-2139 |
| language | Russian |
| publishDate | 2016-10-01 |
| publisher | Practical Medicine Publishing House |
| record_format | Article |
| series | Клиническая онкогематология |
| spelling | doaj-art-c78ac88cbb084e2987635e6a0503a6cb2025-08-20T03:22:57ZrusPractical Medicine Publishing HouseКлиническая онкогематология1997-69332500-21392016-10-019443844510.21320/2500-2139-2016-9-4-438-445Elotuzumab for Treatment of Multiple Myeloma (Literature Review)OM Votyakova0NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478Chemotherapy has been the main treatment option for multiple myeloma for several decades. However, a considerable increase in the life expectancy was observed in multiple myeloma patients when thalidomide, bortezomib and lenalidomide had been introduced into clinical practice. Nevertheless, the disease remains incurable and there is an unmet need in fundamentally new treatment methods. Elotuzumab is a humanized IgG1 monoclonal antibody that specifically targets SLAMF7, an antigen belonging to the signaling lymphocytic activation molecule family, with its high expression detected on myeloma cells. This review presents the mechanism of action of elotuzumab, preclinical data and the main clinical studies of this monoclonal antibody.http://bloodjournal.ru/en/elotuzumab-for-treatment-of-multiple-myeloma-literature-review/monoclonal antibodieselotuzumabclinical studiesmultiple myeloma |
| spellingShingle | OM Votyakova Elotuzumab for Treatment of Multiple Myeloma (Literature Review) Клиническая онкогематология monoclonal antibodies elotuzumab clinical studies multiple myeloma |
| title | Elotuzumab for Treatment of Multiple Myeloma (Literature Review) |
| title_full | Elotuzumab for Treatment of Multiple Myeloma (Literature Review) |
| title_fullStr | Elotuzumab for Treatment of Multiple Myeloma (Literature Review) |
| title_full_unstemmed | Elotuzumab for Treatment of Multiple Myeloma (Literature Review) |
| title_short | Elotuzumab for Treatment of Multiple Myeloma (Literature Review) |
| title_sort | elotuzumab for treatment of multiple myeloma literature review |
| topic | monoclonal antibodies elotuzumab clinical studies multiple myeloma |
| url | http://bloodjournal.ru/en/elotuzumab-for-treatment-of-multiple-myeloma-literature-review/ |
| work_keys_str_mv | AT omvotyakova elotuzumabfortreatmentofmultiplemyelomaliteraturereview |