Kawasaki like illness due to COVID-19: a review of the literature
Introduction: Viral infections have been described as triggers for Kawasaki Disease (KD), a medium vessel vasculitis that affects young children. Akin to the H1N1 pandemic in 2009, there is a similar rise in the incidence of KD in children affected with Coronavirus disease 2019 (COVID-19). Severe A...
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The Journal of Infection in Developing Countries
2021-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/14185 |
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| author | Yulin Fang Veeraraghavan Meyyur Aravamudan Gurusaravanan Kutti Sridharan Keyur Kamlesh Mehta Ramkumar Sekhar Nagendra Boopathy Senguttuvan Indumathi Venkatachalam Muhammad Bilal Abid |
| author_facet | Yulin Fang Veeraraghavan Meyyur Aravamudan Gurusaravanan Kutti Sridharan Keyur Kamlesh Mehta Ramkumar Sekhar Nagendra Boopathy Senguttuvan Indumathi Venkatachalam Muhammad Bilal Abid |
| author_sort | Yulin Fang |
| collection | DOAJ |
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Introduction: Viral infections have been described as triggers for Kawasaki Disease (KD), a medium vessel vasculitis that affects young children. Akin to the H1N1 pandemic in 2009, there is a similar rise in the incidence of KD in children affected with Coronavirus disease 2019 (COVID-19). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been reported to induce an exaggerated systemic inflammatory response resulting in multi-organ involvement, particularly initiated with pulmonary parenchymal damage. This review article will discuss KD-like manifestations in COVID-19 patients in the pediatric cohort.
Methodology: Search terms “Kawasaki” “COVID-19” “SARS-COV-2” “PIM-TS” and “MIS-C” were used to look for relevant articles in PubMed and Google Scholar published in the last 5 years.
Results: There is some evidence to suggest that SARS-CoV-2 stimulates dysfunctional and hyperactive immune reactions mimicking KD in young patients.
Conclusions: Therapeutic options, both investigational and repurposed, include intravenous immunoglobulins, steroids and anticoagulation. More studies are required to evaluate the effectiveness of these treatment options.
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| format | Article |
| id | doaj-art-c7846a62ec4946f9acbc0c1c8d08b8eb |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2021-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-c7846a62ec4946f9acbc0c1c8d08b8eb2025-08-20T02:57:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802021-05-01150510.3855/jidc.14185Kawasaki like illness due to COVID-19: a review of the literatureYulin Fang0Veeraraghavan Meyyur Aravamudan1Gurusaravanan Kutti Sridharan 2Keyur Kamlesh Mehta3Ramkumar Sekhar4Nagendra Boopathy Senguttuvan 5Indumathi Venkatachalam6Muhammad Bilal Abid7Ministry of Health Holdings, SingaporeDepartment of Medicine, Woodlands Health Campus, SingaporeBanner University Medical Centre, University of Arizona, Tucson, AZ, United StatesChildren’s Heart Institute, The Heart Program at Inova Children’s Hospital, VA, United StatesDepartment of Cardiology, Khoo Teck Puat Hospital, SingaporeSri Ramachandra Medical College and Research Institute, Chennai, IndiaDepartment of Infectious Disease, Singapore General Hospital, SingaporeDivisions of Infectious Diseases and Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, United States Introduction: Viral infections have been described as triggers for Kawasaki Disease (KD), a medium vessel vasculitis that affects young children. Akin to the H1N1 pandemic in 2009, there is a similar rise in the incidence of KD in children affected with Coronavirus disease 2019 (COVID-19). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been reported to induce an exaggerated systemic inflammatory response resulting in multi-organ involvement, particularly initiated with pulmonary parenchymal damage. This review article will discuss KD-like manifestations in COVID-19 patients in the pediatric cohort. Methodology: Search terms “Kawasaki” “COVID-19” “SARS-COV-2” “PIM-TS” and “MIS-C” were used to look for relevant articles in PubMed and Google Scholar published in the last 5 years. Results: There is some evidence to suggest that SARS-CoV-2 stimulates dysfunctional and hyperactive immune reactions mimicking KD in young patients. Conclusions: Therapeutic options, both investigational and repurposed, include intravenous immunoglobulins, steroids and anticoagulation. More studies are required to evaluate the effectiveness of these treatment options. https://jidc.org/index.php/journal/article/view/14185Kawasaki-like diseaseCOVID-19SARS-COV-2 |
| spellingShingle | Yulin Fang Veeraraghavan Meyyur Aravamudan Gurusaravanan Kutti Sridharan Keyur Kamlesh Mehta Ramkumar Sekhar Nagendra Boopathy Senguttuvan Indumathi Venkatachalam Muhammad Bilal Abid Kawasaki like illness due to COVID-19: a review of the literature Journal of Infection in Developing Countries Kawasaki-like disease COVID-19 SARS-COV-2 |
| title | Kawasaki like illness due to COVID-19: a review of the literature |
| title_full | Kawasaki like illness due to COVID-19: a review of the literature |
| title_fullStr | Kawasaki like illness due to COVID-19: a review of the literature |
| title_full_unstemmed | Kawasaki like illness due to COVID-19: a review of the literature |
| title_short | Kawasaki like illness due to COVID-19: a review of the literature |
| title_sort | kawasaki like illness due to covid 19 a review of the literature |
| topic | Kawasaki-like disease COVID-19 SARS-COV-2 |
| url | https://jidc.org/index.php/journal/article/view/14185 |
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