PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT
The article reviews scientific literature on serious side effects of non-steroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics widely used to treat acute and chronic pain. In order to reduce the incidence of side effects in clinical practice, oral combinations of NSAIDs and opioids are us...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2019-07-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/335 |
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| _version_ | 1850028751901949952 |
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| author | YU. А. KOLESNIKOV |
| author_facet | YU. А. KOLESNIKOV |
| author_sort | YU. А. KOLESNIKOV |
| collection | DOAJ |
| description | The article reviews scientific literature on serious side effects of non-steroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics widely used to treat acute and chronic pain. In order to reduce the incidence of side effects in clinical practice, oral combinations of NSAIDs and opioids are used. Unfortunately, the efficacy and safety of these combinations also do not meet contemporary requirements for analgesics. Local use of NSAIDs and opioids is one of the alternatives, which will reduce the dose of systemically administered drugs. Peripheral mechanisms play a key role in systemic mu-opioid analgesia. The use of these mechanisms when developing medication for pain relief offers promising prospects in the treatment of acute and chronic pain. |
| format | Article |
| id | doaj-art-c782d251f9a549daaf7f40e9a5dba77d |
| institution | DOAJ |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-c782d251f9a549daaf7f40e9a5dba77d2025-08-20T02:59:45ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532019-07-01163414710.21292/2078-5658-2019-16-3-41-47314PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENTYU. А. KOLESNIKOV0Kordamed ASThe article reviews scientific literature on serious side effects of non-steroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics widely used to treat acute and chronic pain. In order to reduce the incidence of side effects in clinical practice, oral combinations of NSAIDs and opioids are used. Unfortunately, the efficacy and safety of these combinations also do not meet contemporary requirements for analgesics. Local use of NSAIDs and opioids is one of the alternatives, which will reduce the dose of systemically administered drugs. Peripheral mechanisms play a key role in systemic mu-opioid analgesia. The use of these mechanisms when developing medication for pain relief offers promising prospects in the treatment of acute and chronic pain.https://www.vair-journal.com/jour/article/view/335nsaidsopioidside effectsperipheral mechanismstopical |
| spellingShingle | YU. А. KOLESNIKOV PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT Вестник анестезиологии и реаниматологии nsaids opioid side effects peripheral mechanisms topical |
| title | PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT |
| title_full | PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT |
| title_fullStr | PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT |
| title_full_unstemmed | PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT |
| title_short | PROSPECTS OF USING A COMBINATION OF LOCALLY INJECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND OPIOIDS IN PERIPHERAL PAIN MANAGEMENT |
| title_sort | prospects of using a combination of locally injected non steroidal anti inflammatory drugs and opioids in peripheral pain management |
| topic | nsaids opioid side effects peripheral mechanisms topical |
| url | https://www.vair-journal.com/jour/article/view/335 |
| work_keys_str_mv | AT yuakolesnikov prospectsofusingacombinationoflocallyinjectednonsteroidalantiinflammatorydrugsandopioidsinperipheralpainmanagement |