Osteoprotegerin in Cardiometabolic Disorders
Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for CVD. T...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/564934 |
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| author | C. Pérez de Ciriza A. Lawrie N. Varo |
| author_facet | C. Pérez de Ciriza A. Lawrie N. Varo |
| author_sort | C. Pérez de Ciriza |
| collection | DOAJ |
| description | Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for CVD. This review focuses on the relationship between circulating OPG and different endocrine cardiometabolic alterations such as type 1 and 2 diabetes. The association of OPG with diabetic complications (neuropathy, nephropathy, or retinopathy) as well as with atherosclerosis, coronary artery calcification, morbidity, and mortality is pointed out. Moreover, OPG modulation by different treatments is also established. Besides, other associated diseases such as obesity, hypertension, and metabolic syndrome, which are known cardiovascular risk factors, are also considered. |
| format | Article |
| id | doaj-art-c7820bb30eb040d1b0a9317230fc6867 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c7820bb30eb040d1b0a9317230fc68672025-02-03T01:02:54ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/564934564934Osteoprotegerin in Cardiometabolic DisordersC. Pérez de Ciriza0A. Lawrie1N. Varo2Department of Clinical Chemistry, Clínica Universidad de Navarra, Avenida Pío XII 36, 31008 Pamplona, SpainDepartment of Cardiovascular Science, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UKDepartment of Clinical Chemistry, Clínica Universidad de Navarra, Avenida Pío XII 36, 31008 Pamplona, SpainOsteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for CVD. This review focuses on the relationship between circulating OPG and different endocrine cardiometabolic alterations such as type 1 and 2 diabetes. The association of OPG with diabetic complications (neuropathy, nephropathy, or retinopathy) as well as with atherosclerosis, coronary artery calcification, morbidity, and mortality is pointed out. Moreover, OPG modulation by different treatments is also established. Besides, other associated diseases such as obesity, hypertension, and metabolic syndrome, which are known cardiovascular risk factors, are also considered.http://dx.doi.org/10.1155/2015/564934 |
| spellingShingle | C. Pérez de Ciriza A. Lawrie N. Varo Osteoprotegerin in Cardiometabolic Disorders International Journal of Endocrinology |
| title | Osteoprotegerin in Cardiometabolic Disorders |
| title_full | Osteoprotegerin in Cardiometabolic Disorders |
| title_fullStr | Osteoprotegerin in Cardiometabolic Disorders |
| title_full_unstemmed | Osteoprotegerin in Cardiometabolic Disorders |
| title_short | Osteoprotegerin in Cardiometabolic Disorders |
| title_sort | osteoprotegerin in cardiometabolic disorders |
| url | http://dx.doi.org/10.1155/2015/564934 |
| work_keys_str_mv | AT cperezdeciriza osteoprotegerinincardiometabolicdisorders AT alawrie osteoprotegerinincardiometabolicdisorders AT nvaro osteoprotegerinincardiometabolicdisorders |