Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats
<b>Aim: </b>Cisplatin (CIS), an antineoplastic agent, shows serious side effects such as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this study was to investigate whether ThQ treatment has...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2024-03-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1440 |
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| author | Sercan Kaya Tuba Yalcin |
| author_facet | Sercan Kaya Tuba Yalcin |
| author_sort | Sercan Kaya |
| collection | DOAJ |
| description | <b>Aim: </b>Cisplatin (CIS), an antineoplastic agent, shows serious side effects such
as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many
beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this
study was to investigate whether ThQ treatment has hepatoprotective effect
in CIS-induced hepatotoxicity model in rats and also to determine how CIS
and/or ThQ treatments affect OTULIN levels, one of the deubiquitinases, in
liver tissue.<p>
<b>Materials and Methods: </b>The 28 rats used in the study control (application
not done), CIS (7 mg/kg CIS, first day of experiment, intraperitoneal), CIS+ThQ
(7 mg/kg CIS, first day of experiment, intraperitoneal + 10 mg/kg/day ThQ,
oral gavage) and ThQ (10 mg/kg/day ThQ, oral gavage) were divided into four
equal groups (n=7). The experiment was terminated upon completion of all
applications (day 15). The effects of CIS and\or ThQ apps on liver tissues were
examined biochemically, histopathologically and immunohistochemically.<p>
<b>Results: </b>CIS application increased liver enzyme levels, histopathological
changes, inflammation, oxidative stress and apoptosis in liver tissue and
caused a decrease in OTULIN level. However, ThQ administration showed a
positive regulatory effect on CIS-induced changes in liver tissue..<p>
<b>Conclusion: </b>ThQ supplementation has a hepatoprotective effect against CISinduced
liver tissue damage. |
| format | Article |
| id | doaj-art-c77f182e54da423381783fd31d75a79e |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-c77f182e54da423381783fd31d75a79e2025-02-03T11:25:37ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532024-03-01401191440Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in ratsSercan KayaTuba Yalcin<b>Aim: </b>Cisplatin (CIS), an antineoplastic agent, shows serious side effects such as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this study was to investigate whether ThQ treatment has hepatoprotective effect in CIS-induced hepatotoxicity model in rats and also to determine how CIS and/or ThQ treatments affect OTULIN levels, one of the deubiquitinases, in liver tissue.<p> <b>Materials and Methods: </b>The 28 rats used in the study control (application not done), CIS (7 mg/kg CIS, first day of experiment, intraperitoneal), CIS+ThQ (7 mg/kg CIS, first day of experiment, intraperitoneal + 10 mg/kg/day ThQ, oral gavage) and ThQ (10 mg/kg/day ThQ, oral gavage) were divided into four equal groups (n=7). The experiment was terminated upon completion of all applications (day 15). The effects of CIS and\or ThQ apps on liver tissues were examined biochemically, histopathologically and immunohistochemically.<p> <b>Results: </b>CIS application increased liver enzyme levels, histopathological changes, inflammation, oxidative stress and apoptosis in liver tissue and caused a decrease in OTULIN level. However, ThQ administration showed a positive regulatory effect on CIS-induced changes in liver tissue..<p> <b>Conclusion: </b>ThQ supplementation has a hepatoprotective effect against CISinduced liver tissue damage.http://eurasianjvetsci.org/pdf.php3?id=1440hepatotoxicityotulincisplatinthymoquinone |
| spellingShingle | Sercan Kaya Tuba Yalcin Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats Eurasian Journal of Veterinary Sciences hepatotoxicity otulin cisplatin thymoquinone |
| title | Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats |
| title_full | Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats |
| title_fullStr | Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats |
| title_full_unstemmed | Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats |
| title_short | Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats |
| title_sort | potential therapeutic effect of thymoquinone on cisplatin induced hepatotoxicity in rats |
| topic | hepatotoxicity otulin cisplatin thymoquinone |
| url | http://eurasianjvetsci.org/pdf.php3?id=1440 |
| work_keys_str_mv | AT sercankaya potentialtherapeuticeffectofthymoquinoneoncisplatininducedhepatotoxicityinrats AT tubayalcin potentialtherapeuticeffectofthymoquinoneoncisplatininducedhepatotoxicityinrats |