Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats
<b>Aim: </b>Cisplatin (CIS), an antineoplastic agent, shows serious side effects such as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this study was to investigate whether ThQ treatment has...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2024-03-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1440 |
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| Summary: | <b>Aim: </b>Cisplatin (CIS), an antineoplastic agent, shows serious side effects such
as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many
beneficial effects such as anti-inflammatory, anti-tumoral. The aim of this
study was to investigate whether ThQ treatment has hepatoprotective effect
in CIS-induced hepatotoxicity model in rats and also to determine how CIS
and/or ThQ treatments affect OTULIN levels, one of the deubiquitinases, in
liver tissue.<p>
<b>Materials and Methods: </b>The 28 rats used in the study control (application
not done), CIS (7 mg/kg CIS, first day of experiment, intraperitoneal), CIS+ThQ
(7 mg/kg CIS, first day of experiment, intraperitoneal + 10 mg/kg/day ThQ,
oral gavage) and ThQ (10 mg/kg/day ThQ, oral gavage) were divided into four
equal groups (n=7). The experiment was terminated upon completion of all
applications (day 15). The effects of CIS and\or ThQ apps on liver tissues were
examined biochemically, histopathologically and immunohistochemically.<p>
<b>Results: </b>CIS application increased liver enzyme levels, histopathological
changes, inflammation, oxidative stress and apoptosis in liver tissue and
caused a decrease in OTULIN level. However, ThQ administration showed a
positive regulatory effect on CIS-induced changes in liver tissue..<p>
<b>Conclusion: </b>ThQ supplementation has a hepatoprotective effect against CISinduced
liver tissue damage. |
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| ISSN: | 1309-6958 2146-1953 |