Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences
There is an emerging body of work indicating that genes, epigenetics, and the in utero environment can impact whether or not a child is obese. While certain genes have been identified that increase one’s risk for becoming obese, other factors such as excess gestational weight gain, gestational diabe...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/463850 |
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| author | Kyung E. Rhee Suzanne Phelan Jeanne McCaffery |
| author_facet | Kyung E. Rhee Suzanne Phelan Jeanne McCaffery |
| author_sort | Kyung E. Rhee |
| collection | DOAJ |
| description | There is an emerging body of work indicating that genes, epigenetics, and the in utero environment can impact whether or not a child is obese. While certain genes have been identified that increase one’s risk for becoming obese, other factors such as excess gestational weight gain, gestational diabetes mellitus, and smoking can also influence this risk. Understanding these influences can help to inform which behaviors and exposures should be targeted if we are to decrease the prevalence of obesity. By helping parents and young children change certain behaviors and exposures during critical time periods, we may be able to alter or modify one’s genetic predisposition. However, further research is needed to determine which efforts are effective at decreasing the incidence of obesity and to develop new methods of prevention. In this paper, we will discuss how genes, epigenetics, and in utero influences affect the development of obesity. We will then discuss current efforts to alter these influences and suggest future directions for this work. |
| format | Article |
| id | doaj-art-c77bb4e982854664a3b99e4c48149a48 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-c77bb4e982854664a3b99e4c48149a482025-02-03T06:01:45ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/463850463850Early Determinants of Obesity: Genetic, Epigenetic, and In Utero InfluencesKyung E. Rhee0Suzanne Phelan1Jeanne McCaffery2Department of Pediatrics, University of California, 4305 University Avenue, Suite 590, San Diego, CA 92105, USADepartment of Kinesiology, California Polytechnic State University, San Luis Obispo, CA 93407, USADepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAThere is an emerging body of work indicating that genes, epigenetics, and the in utero environment can impact whether or not a child is obese. While certain genes have been identified that increase one’s risk for becoming obese, other factors such as excess gestational weight gain, gestational diabetes mellitus, and smoking can also influence this risk. Understanding these influences can help to inform which behaviors and exposures should be targeted if we are to decrease the prevalence of obesity. By helping parents and young children change certain behaviors and exposures during critical time periods, we may be able to alter or modify one’s genetic predisposition. However, further research is needed to determine which efforts are effective at decreasing the incidence of obesity and to develop new methods of prevention. In this paper, we will discuss how genes, epigenetics, and in utero influences affect the development of obesity. We will then discuss current efforts to alter these influences and suggest future directions for this work.http://dx.doi.org/10.1155/2012/463850 |
| spellingShingle | Kyung E. Rhee Suzanne Phelan Jeanne McCaffery Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences International Journal of Pediatrics |
| title | Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences |
| title_full | Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences |
| title_fullStr | Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences |
| title_full_unstemmed | Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences |
| title_short | Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences |
| title_sort | early determinants of obesity genetic epigenetic and in utero influences |
| url | http://dx.doi.org/10.1155/2012/463850 |
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