From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery
Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interact...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/1/15 |
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| author | Lijuan Xie Fengxu Gan Yun Hu Yibin Zheng Junshan Lan Yuting Liu Xiaofang Zhou Jianyu Zheng Xing Zhou Jie Lou |
| author_facet | Lijuan Xie Fengxu Gan Yun Hu Yibin Zheng Junshan Lan Yuting Liu Xiaofang Zhou Jianyu Zheng Xing Zhou Jie Lou |
| author_sort | Lijuan Xie |
| collection | DOAJ |
| description | Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interaction capabilities. These systems utilize nanoparticles shielded and directed by platelet membrane coatings for efficient drug delivery. This review highlights the role of platelets in cancer therapy, summarizes the advancements in platelet-based drug delivery systems, and discusses their integration with other cancer treatments. Additionally, it addresses the limitations and challenges of platelet-mediated drug delivery, offering insights into future developments in this innovative field. |
| format | Article |
| id | doaj-art-c77b75dcc0a44379b713518c223301ab |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-c77b75dcc0a44379b713518c223301ab2025-01-24T13:36:07ZengMDPI AGJournal of Functional Biomaterials2079-49832025-01-011611510.3390/jfb16010015From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug DeliveryLijuan Xie0Fengxu Gan1Yun Hu2Yibin Zheng3Junshan Lan4Yuting Liu5Xiaofang Zhou6Jianyu Zheng7Xing Zhou8Jie Lou9School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, School of Rehabilitation, Kunming Medical University, Kunming 650500, ChinaSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, ChinaBiomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interaction capabilities. These systems utilize nanoparticles shielded and directed by platelet membrane coatings for efficient drug delivery. This review highlights the role of platelets in cancer therapy, summarizes the advancements in platelet-based drug delivery systems, and discusses their integration with other cancer treatments. Additionally, it addresses the limitations and challenges of platelet-mediated drug delivery, offering insights into future developments in this innovative field.https://www.mdpi.com/2079-4983/16/1/15cancerplateletcell membranebionic nanosystemstargeted therapy |
| spellingShingle | Lijuan Xie Fengxu Gan Yun Hu Yibin Zheng Junshan Lan Yuting Liu Xiaofang Zhou Jianyu Zheng Xing Zhou Jie Lou From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery Journal of Functional Biomaterials cancer platelet cell membrane bionic nanosystems targeted therapy |
| title | From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery |
| title_full | From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery |
| title_fullStr | From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery |
| title_full_unstemmed | From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery |
| title_short | From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery |
| title_sort | from blood to therapy the revolutionary application of platelets in cancer targeted drug delivery |
| topic | cancer platelet cell membrane bionic nanosystems targeted therapy |
| url | https://www.mdpi.com/2079-4983/16/1/15 |
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