Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients
The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/545068 |
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| author | Dagmar Horáková Kateřina Azeem Radka Benešová Dalibor Pastucha Vladimír Horák Lenka Dumbrovská Arnošt Martínek Dalibor Novotný Zdeněk Švagera Milada Hobzová Dana Galuszková Vladimír Janout Sandra Doněvská Jana Vrbková Helena Kollárová |
| author_facet | Dagmar Horáková Kateřina Azeem Radka Benešová Dalibor Pastucha Vladimír Horák Lenka Dumbrovská Arnošt Martínek Dalibor Novotný Zdeněk Švagera Milada Hobzová Dana Galuszková Vladimír Janout Sandra Doněvská Jana Vrbková Helena Kollárová |
| author_sort | Dagmar Horáková |
| collection | DOAJ |
| description | The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients. |
| format | Article |
| id | doaj-art-c770d97f7f6e46cbaa7b4dc2c89b97f1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c770d97f7f6e46cbaa7b4dc2c89b97f12025-02-03T06:08:34ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/545068545068Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic PatientsDagmar Horáková0Kateřina Azeem1Radka Benešová2Dalibor Pastucha3Vladimír Horák4Lenka Dumbrovská5Arnošt Martínek6Dalibor Novotný7Zdeněk Švagera8Milada Hobzová9Dana Galuszková10Vladimír Janout11Sandra Doněvská12Jana Vrbková13Helena Kollárová14Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicDepartment of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicClinic of Internal Medicine, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech RepublicDepartment of Sports and Exercise Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech RepublicDepartment of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicDepartment of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicClinic of Internal Medicine, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech RepublicDepartment of Clinical Biochemistry and Immunogenetics, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech RepublicDepartment of Clinical Biochemistry, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech RepublicDepartment of Respiratory Medicine, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech RepublicDepartment of Transfusion Medicine, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech RepublicDepartment of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicDepartment of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech RepublicThe study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.http://dx.doi.org/10.1155/2015/545068 |
| spellingShingle | Dagmar Horáková Kateřina Azeem Radka Benešová Dalibor Pastucha Vladimír Horák Lenka Dumbrovská Arnošt Martínek Dalibor Novotný Zdeněk Švagera Milada Hobzová Dana Galuszková Vladimír Janout Sandra Doněvská Jana Vrbková Helena Kollárová Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients International Journal of Endocrinology |
| title | Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients |
| title_full | Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients |
| title_fullStr | Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients |
| title_full_unstemmed | Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients |
| title_short | Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients |
| title_sort | total and high molecular weight adiponectin levels and prediction of cardiovascular risk in diabetic patients |
| url | http://dx.doi.org/10.1155/2015/545068 |
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