New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities
A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a–e)/carbothioamides 8(f–j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a–e)/arylisothiocyanates 7(f–j) with...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/682603 |
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| author | Reddivari Chenna Krishna Reddy Syed Rasheed Devineni Subba Rao Shaik Adam Yellala Venkata Rami Reddy Chamarthi Naga Raju |
| author_facet | Reddivari Chenna Krishna Reddy Syed Rasheed Devineni Subba Rao Shaik Adam Yellala Venkata Rami Reddy Chamarthi Naga Raju |
| author_sort | Reddivari Chenna Krishna Reddy |
| collection | DOAJ |
| description | A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a–e)/carbothioamides 8(f–j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a–e)/arylisothiocyanates 7(f–j) with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile (4). Compound 4 was synthesized in high yields (94%) by the condensation reaction of febuxostat (1) with piperazine using a selective reagent such as propylphosphonic anhydride (T3P). Antiviral activity against Tobacco mosaic virus (TMV) and antimicrobial activity of the synthesized compounds were evaluated. Biological data revealed that 4-nitrophenyl substituted urea 8d, and 3-bromophenyl substituted thiourea 8f exhibited promising antiviral activities. Moreover, 4-fluorophenyl substituted urea 8a, 4-nitrophenyl substituted urea 8d, 3-bromophenyl substituted thiourea 8f, and 2,4-dichlorophenyl substituted thiourea 8j exhibited potent antimicrobial activity. |
| format | Article |
| id | doaj-art-c7708c3e07ac4118b70cc3653e41a094 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c7708c3e07ac4118b70cc3653e41a0942025-02-03T01:28:05ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/682603682603New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial ActivitiesReddivari Chenna Krishna Reddy0Syed Rasheed1Devineni Subba Rao2Shaik Adam3Yellala Venkata Rami Reddy4Chamarthi Naga Raju5Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh-517 502, IndiaDepartment of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh-517 502, IndiaDepartment of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh-517 502, IndiaDepartment of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh-517 502, IndiaDepartment of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh-517 502, IndiaDepartment of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh-517 502, IndiaA series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a–e)/carbothioamides 8(f–j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a–e)/arylisothiocyanates 7(f–j) with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile (4). Compound 4 was synthesized in high yields (94%) by the condensation reaction of febuxostat (1) with piperazine using a selective reagent such as propylphosphonic anhydride (T3P). Antiviral activity against Tobacco mosaic virus (TMV) and antimicrobial activity of the synthesized compounds were evaluated. Biological data revealed that 4-nitrophenyl substituted urea 8d, and 3-bromophenyl substituted thiourea 8f exhibited promising antiviral activities. Moreover, 4-fluorophenyl substituted urea 8a, 4-nitrophenyl substituted urea 8d, 3-bromophenyl substituted thiourea 8f, and 2,4-dichlorophenyl substituted thiourea 8j exhibited potent antimicrobial activity.http://dx.doi.org/10.1155/2013/682603 |
| spellingShingle | Reddivari Chenna Krishna Reddy Syed Rasheed Devineni Subba Rao Shaik Adam Yellala Venkata Rami Reddy Chamarthi Naga Raju New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities The Scientific World Journal |
| title | New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities |
| title_full | New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities |
| title_fullStr | New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities |
| title_full_unstemmed | New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities |
| title_short | New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities |
| title_sort | new urea and thiourea derivatives of piperazine doped with febuxostat synthesis and evaluation of anti tmv and antimicrobial activities |
| url | http://dx.doi.org/10.1155/2013/682603 |
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