Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study
BackgroundPrevious studies have evaluated the safety and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for the treatment of Parkinson’s disease (PD). However, the mechanism underlying the effect of taVNS on PD remains to be elucidated. This study aimed to investigate the immed...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1444703/full |
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| author | Chengwei Fu Chengwei Fu Chengwei Fu Xiaoyan Hou Chunye Zheng Yue Zhang Zhijie Gao Zhijie Gao Zhaoxian Yan Yongsong Ye Bo Liu |
| author_facet | Chengwei Fu Chengwei Fu Chengwei Fu Xiaoyan Hou Chunye Zheng Yue Zhang Zhijie Gao Zhijie Gao Zhaoxian Yan Yongsong Ye Bo Liu |
| author_sort | Chengwei Fu |
| collection | DOAJ |
| description | BackgroundPrevious studies have evaluated the safety and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for the treatment of Parkinson’s disease (PD). However, the mechanism underlying the effect of taVNS on PD remains to be elucidated. This study aimed to investigate the immediate effects of taVNS in PD patients.MethodsThis crossover self-controlled study included 50 PD patients. Each patient underwent three sessions of resting-state functional magnetic resonance imaging (rs-fMRI) under three conditions: real taVNS, sham taVNS, and no taVNS intervention. We analyzed whole-brain amplitude of low-frequency fluctuations (ALFF) from preprocessed fMRI data across different intervention conditions. ALFF values in altered brain regions were correlated with clinical symptoms in PD patients.ResultsForty-seven participants completed the study and were included in the final analysis. Real taVNS was associated with a widespread decrease in ALFF in the right hemisphere, including the superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus (voxel p < 0.001, GRF corrected). The ALFF value in the right superior parietal lobule during real taVNS was negatively correlated with the Unified Parkinson’s Disease Rating Scale Part III (r = −0.417, p = 0.004, Bonferroni corrected).ConclusionTaVNS could immediately modulate the functional activity of brain regions involved in superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus. These findings offer preliminary insights into the mechanism of taVNS in treating PD and bolster confidence in its long-term therapeutic potential. TaVNS appears to reduce ALFF values in specific brain regions, suggesting a potential modulation mechanism for treating PD. |
| format | Article |
| id | doaj-art-c7627ce352e14d2e9537b8cb65b1e5ca |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-c7627ce352e14d2e9537b8cb65b1e5ca2025-01-29T14:07:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-10-011610.3389/fnagi.2024.14447031444703Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI studyChengwei Fu0Chengwei Fu1Chengwei Fu2Xiaoyan Hou3Chunye Zheng4Yue Zhang5Zhijie Gao6Zhijie Gao7Zhaoxian Yan8Yongsong Ye9Bo Liu10Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaDepartment of Acupuncture, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaBackgroundPrevious studies have evaluated the safety and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for the treatment of Parkinson’s disease (PD). However, the mechanism underlying the effect of taVNS on PD remains to be elucidated. This study aimed to investigate the immediate effects of taVNS in PD patients.MethodsThis crossover self-controlled study included 50 PD patients. Each patient underwent three sessions of resting-state functional magnetic resonance imaging (rs-fMRI) under three conditions: real taVNS, sham taVNS, and no taVNS intervention. We analyzed whole-brain amplitude of low-frequency fluctuations (ALFF) from preprocessed fMRI data across different intervention conditions. ALFF values in altered brain regions were correlated with clinical symptoms in PD patients.ResultsForty-seven participants completed the study and were included in the final analysis. Real taVNS was associated with a widespread decrease in ALFF in the right hemisphere, including the superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus (voxel p < 0.001, GRF corrected). The ALFF value in the right superior parietal lobule during real taVNS was negatively correlated with the Unified Parkinson’s Disease Rating Scale Part III (r = −0.417, p = 0.004, Bonferroni corrected).ConclusionTaVNS could immediately modulate the functional activity of brain regions involved in superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus. These findings offer preliminary insights into the mechanism of taVNS in treating PD and bolster confidence in its long-term therapeutic potential. TaVNS appears to reduce ALFF values in specific brain regions, suggesting a potential modulation mechanism for treating PD.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1444703/fullParkinson’s diseasetranscutaneous auricular vagus nerve stimulationfunctional magnetic resonance imagingamplitude of low-frequency fluctuationsneuroimagingAuricular therapy |
| spellingShingle | Chengwei Fu Chengwei Fu Chengwei Fu Xiaoyan Hou Chunye Zheng Yue Zhang Zhijie Gao Zhijie Gao Zhaoxian Yan Yongsong Ye Bo Liu Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study Frontiers in Aging Neuroscience Parkinson’s disease transcutaneous auricular vagus nerve stimulation functional magnetic resonance imaging amplitude of low-frequency fluctuations neuroimaging Auricular therapy |
| title | Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study |
| title_full | Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study |
| title_fullStr | Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study |
| title_full_unstemmed | Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study |
| title_short | Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study |
| title_sort | immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with parkinson s disease a crossover self controlled fmri study |
| topic | Parkinson’s disease transcutaneous auricular vagus nerve stimulation functional magnetic resonance imaging amplitude of low-frequency fluctuations neuroimaging Auricular therapy |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1444703/full |
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