11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses relate...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/5279462 |
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| author | Katarzyna Kosicka Anna Siemiątkowska Franciszek K. Główka |
| author_facet | Katarzyna Kosicka Anna Siemiątkowska Franciszek K. Główka |
| author_sort | Katarzyna Kosicka |
| collection | DOAJ |
| description | Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology of preeclampsia is the deficiency in placental 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), the enzyme which in normal pregnancy protects the fetus from the excess of maternal cortisol. The reduced activity of the enzyme was observed in placentas from pregnancies complicated with preeclampsia. That suggests the overexposure of the developing child to maternal cortisol, which in high levels exerts proapoptotic effects and reduces fetal growth. The fetal growth restriction due to the diminished placental 11β-HSD2 function may be supported by the fact that preeclampsia is often accompanied with fetal hypotrophy. The causes of the reduced function of 11β-HSD2 in placental tissue are still discussed. This paper summarizes the phenomena that may affect the activity of the enzyme at various steps on the way from the gene to the protein. |
| format | Article |
| id | doaj-art-c7589fe9377b4a859f576a31b3893af5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c7589fe9377b4a859f576a31b3893af52025-02-03T01:09:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/5279462527946211β-Hydroxysteroid Dehydrogenase 2 in PreeclampsiaKatarzyna Kosicka0Anna Siemiątkowska1Franciszek K. Główka2Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, PolandDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, PolandDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, PolandPreeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology of preeclampsia is the deficiency in placental 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), the enzyme which in normal pregnancy protects the fetus from the excess of maternal cortisol. The reduced activity of the enzyme was observed in placentas from pregnancies complicated with preeclampsia. That suggests the overexposure of the developing child to maternal cortisol, which in high levels exerts proapoptotic effects and reduces fetal growth. The fetal growth restriction due to the diminished placental 11β-HSD2 function may be supported by the fact that preeclampsia is often accompanied with fetal hypotrophy. The causes of the reduced function of 11β-HSD2 in placental tissue are still discussed. This paper summarizes the phenomena that may affect the activity of the enzyme at various steps on the way from the gene to the protein.http://dx.doi.org/10.1155/2016/5279462 |
| spellingShingle | Katarzyna Kosicka Anna Siemiątkowska Franciszek K. Główka 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia International Journal of Endocrinology |
| title | 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia |
| title_full | 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia |
| title_fullStr | 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia |
| title_full_unstemmed | 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia |
| title_short | 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia |
| title_sort | 11β hydroxysteroid dehydrogenase 2 in preeclampsia |
| url | http://dx.doi.org/10.1155/2016/5279462 |
| work_keys_str_mv | AT katarzynakosicka 11bhydroxysteroiddehydrogenase2inpreeclampsia AT annasiemiatkowska 11bhydroxysteroiddehydrogenase2inpreeclampsia AT franciszekkgłowka 11bhydroxysteroiddehydrogenase2inpreeclampsia |