Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones

Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones

Abstract Background Obesity, a major risk factor for cardiovascular disease (CVD), is associated with hypertension and vascular dysfunction. Perivascular adipose tissue (PVAT), a metabolically active tissue surrounding blood vessels, plays a key role in regulating vascular tone. In obesity, PVAT bec...

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Bibliographic Details
Main Authors: Lisa Ivatt, Mhairi Paul, Allende Miguelez-Crespo, Patrick W. F. Hadoke, Matthew A. Bailey, Ruth A. Morgan, Mark Nixon
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cardiovascular Diabetology
Subjects:
Obesity
Perivascular adipose tissue
Vascular dysfunction
Insulin resistance
Sex-specific response
Online Access:https://doi.org/10.1186/s12933-025-02596-w
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