RNA‐Seq and ChIP‐Seq Identification of Unique and Overlapping Target Genes and Pathways Regulated by TBX4 in Human Pulmonary Fibroblasts and Pericytes

RNA‐Seq and ChIP‐Seq Identification of Unique and Overlapping Target Genes and Pathways Regulated by TBX4 in Human Pulmonary Fibroblasts and Pericytes

ABSTRACT Transcription factor TBX4 rare variants associate with pulmonary arterial hypertension (PAH), particularly in children, and are the second most common cause of heritable PAH. However, TBX4's down‐stream targets and the molecular and cellular pathways these targets regulate remain large...

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Bibliographic Details
Main Authors: Ying Cai, Ling Yan, Joy D. Cogan, Lora K. Hedges, Bethany Nunley, Nick Negretti, Jennifer M. S. Sucre, James West, Eric D. Austin, Rizwan Hamid
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Pulmonary Circulation
Subjects:
ChIP‐seq
extracellular matrix (ECM)
pulmonary arterial hypertension (PAH)
RNA‐seq
T‐Box 4 (TBX4)
Online Access:https://doi.org/10.1002/pul2.70058
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