Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions
Introduction. According to modern data, Oral Allergy Syndrome (OAS) is most often formed by patients sensitized to the birch family: up to 73% of patients allergic to birch experienced OAS. 86% of them experience their oral symptoms year-round, which significantly affects the quality of life of thes...
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| Language: | Russian |
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Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2024-06-01
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| Series: | Аллергология и Иммунология в Педиатрии |
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| Online Access: | https://adair.elpub.ru/jour/article/view/142 |
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| author | T. S. Lepeshkova |
| author_facet | T. S. Lepeshkova |
| author_sort | T. S. Lepeshkova |
| collection | DOAJ |
| description | Introduction. According to modern data, Oral Allergy Syndrome (OAS) is most often formed by patients sensitized to the birch family: up to 73% of patients allergic to birch experienced OAS. 86% of them experience their oral symptoms year-round, which significantly affects the quality of life of these patients. The effectiveness of AIT in the treatment of respiratory allergy symptoms is beyond doubt, while the effect on the manifestations of cross-food allergies requires additional study.Objective. To study the clinical effectiveness of the formation of oral tolerance to fruits and vegetables under the influence of allergen-specific immunotherapy (ASIT) with the allergen Staloral® “Birch pollen allergen” (Stallergenes Greer, France).Material and methods. The study (prospective open comparative longitudinal) included 184 patients with respiratory allergy to birch pollen aged 5 to 16 years with confirmed sensitization to the major molecule (Bet v 1). Children of the main group (n = 134, 7.0 [5.0; 9.0] years) had OAS. Children from the comparison group (n = 50, 7.0 [6.0; 10.0] years) did not have OAS. A clinical examination, general clinical and allergological examinations were carried out for each child. Component allergy diagnostics was performed using a multiplex panel (ISAC-112, ImmunoCAP) for children with OAS (n = 40) who had multiple manifestations of cross-food allergies. Patients of both groups (n = 184) received a three-year course of AIT with the allergen Staloral® “Birch pollen allergen”.Results. In patients with OAS, it was possible to achieve the formation of oral tolerance (total or partial) to fresh vegetables and fruits in 88.81% (n = 119, p = 0.000). There was a decrease in the intensity and duration of respiratory allergy symptoms during the pollination season, and the need for pharmacotherapy after a three-year course of AIT Staloral® “Birch pollen allergen” in children of both groups.Conclusions: three-year AIT with the allergen Staloral® “Birch pollen allergen” is able to form oral tolerance in children with cross food allergies to PR-10 proteins of vegetables and fruits. |
| format | Article |
| id | doaj-art-c73cb87fd8664905abf9d5daa4b618a2 |
| institution | Kabale University |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj-art-c73cb87fd8664905abf9d5daa4b618a22025-08-20T03:57:48ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582024-06-0102688110.53529/2500-1175-2024-2-68-81115Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutionsT. S. Lepeshkova0Federal State Budgetary Educational Institution of Higher Professional Education “The Urals State Medical University” of the Ministry of Health of RussiaIntroduction. According to modern data, Oral Allergy Syndrome (OAS) is most often formed by patients sensitized to the birch family: up to 73% of patients allergic to birch experienced OAS. 86% of them experience their oral symptoms year-round, which significantly affects the quality of life of these patients. The effectiveness of AIT in the treatment of respiratory allergy symptoms is beyond doubt, while the effect on the manifestations of cross-food allergies requires additional study.Objective. To study the clinical effectiveness of the formation of oral tolerance to fruits and vegetables under the influence of allergen-specific immunotherapy (ASIT) with the allergen Staloral® “Birch pollen allergen” (Stallergenes Greer, France).Material and methods. The study (prospective open comparative longitudinal) included 184 patients with respiratory allergy to birch pollen aged 5 to 16 years with confirmed sensitization to the major molecule (Bet v 1). Children of the main group (n = 134, 7.0 [5.0; 9.0] years) had OAS. Children from the comparison group (n = 50, 7.0 [6.0; 10.0] years) did not have OAS. A clinical examination, general clinical and allergological examinations were carried out for each child. Component allergy diagnostics was performed using a multiplex panel (ISAC-112, ImmunoCAP) for children with OAS (n = 40) who had multiple manifestations of cross-food allergies. Patients of both groups (n = 184) received a three-year course of AIT with the allergen Staloral® “Birch pollen allergen”.Results. In patients with OAS, it was possible to achieve the formation of oral tolerance (total or partial) to fresh vegetables and fruits in 88.81% (n = 119, p = 0.000). There was a decrease in the intensity and duration of respiratory allergy symptoms during the pollination season, and the need for pharmacotherapy after a three-year course of AIT Staloral® “Birch pollen allergen” in children of both groups.Conclusions: three-year AIT with the allergen Staloral® “Birch pollen allergen” is able to form oral tolerance in children with cross food allergies to PR-10 proteins of vegetables and fruits.https://adair.elpub.ru/jour/article/view/142childrenoral allergy syndromeallergen-specific immunotherapy |
| spellingShingle | T. S. Lepeshkova Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions Аллергология и Иммунология в Педиатрии children oral allergy syndrome allergen-specific immunotherapy |
| title | Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions |
| title_full | Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions |
| title_fullStr | Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions |
| title_full_unstemmed | Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions |
| title_short | Local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen: solutions |
| title_sort | local manifestations of cross food allergy in children with clinical symptoms of respiratory allergy to birch pollen solutions |
| topic | children oral allergy syndrome allergen-specific immunotherapy |
| url | https://adair.elpub.ru/jour/article/view/142 |
| work_keys_str_mv | AT tslepeshkova localmanifestationsofcrossfoodallergyinchildrenwithclinicalsymptomsofrespiratoryallergytobirchpollensolutions |