Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU
Introduction. We sought to identify possible risk factors associated with mortality in patients with high-risk pulmonary embolism (PE) after intensive care unit (ICU) admission. Patients and Methods. PE patients, diagnosed with computer tomography pulmonary angiography, were included from two ICUs a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/2432808 |
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| author | Begüm Ergan Recai Ergün Taner Çalışkan Kutlay Aydın Murat Emre Tokur Yusuf Savran Uğur Koca Bilgin Cömert Necati Gökmen |
| author_facet | Begüm Ergan Recai Ergün Taner Çalışkan Kutlay Aydın Murat Emre Tokur Yusuf Savran Uğur Koca Bilgin Cömert Necati Gökmen |
| author_sort | Begüm Ergan |
| collection | DOAJ |
| description | Introduction. We sought to identify possible risk factors associated with mortality in patients with high-risk pulmonary embolism (PE) after intensive care unit (ICU) admission. Patients and Methods. PE patients, diagnosed with computer tomography pulmonary angiography, were included from two ICUs and were categorized into groups: group 1 high-risk patients and group 2 intermediate/low-risk patients. Results. Fifty-six patients were included. Of them, 41 (73.2%) were group 1 and 15 (26.7%) were group 2. When compared to group 2, need for vasopressor therapy (0 vs 68.3%; p<0.001) and need for invasive mechanical ventilation (6.7 vs 36.6%; p=0.043) were more frequent in group 1. The treatment of choice for group 1 was thrombolytic therapy in 29 (70.7%) and anticoagulation in 12 (29.3%) patients. ICU mortality for group 1 was 31.7% (n=13). In multivariate logistic regression analysis, APACHE II score >18 (OR 42.47 95% CI 1.50–1201.1), invasive mechanical ventilation (OR 30.10 95% CI 1.96–463.31), and thrombolytic therapy (OR 0.03 95% CI 0.01–0.98) were found as independent predictors of mortality. Conclusion. In high-risk PE, admission APACHE II score and need for invasive mechanical ventilation may predict death in ICU. Thrombolytic therapy seems to be beneficial in these patients. |
| format | Article |
| id | doaj-art-c7359c715dca44c68379fe02958a021a |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-c7359c715dca44c68379fe02958a021a2025-02-03T05:49:27ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/24328082432808Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICUBegüm Ergan0Recai Ergün1Taner Çalışkan2Kutlay Aydın3Murat Emre Tokur4Yusuf Savran5Uğur Koca6Bilgin Cömert7Necati Gökmen8School of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeyDışkapı Yıldırım Beyazıt Education and Research Hospital, Medical Intensive Care Unit, Ankara, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeySchool of Medicine, Intensive Care Unit, Dokuz Eylül University, Izmir, TurkeyIntroduction. We sought to identify possible risk factors associated with mortality in patients with high-risk pulmonary embolism (PE) after intensive care unit (ICU) admission. Patients and Methods. PE patients, diagnosed with computer tomography pulmonary angiography, were included from two ICUs and were categorized into groups: group 1 high-risk patients and group 2 intermediate/low-risk patients. Results. Fifty-six patients were included. Of them, 41 (73.2%) were group 1 and 15 (26.7%) were group 2. When compared to group 2, need for vasopressor therapy (0 vs 68.3%; p<0.001) and need for invasive mechanical ventilation (6.7 vs 36.6%; p=0.043) were more frequent in group 1. The treatment of choice for group 1 was thrombolytic therapy in 29 (70.7%) and anticoagulation in 12 (29.3%) patients. ICU mortality for group 1 was 31.7% (n=13). In multivariate logistic regression analysis, APACHE II score >18 (OR 42.47 95% CI 1.50–1201.1), invasive mechanical ventilation (OR 30.10 95% CI 1.96–463.31), and thrombolytic therapy (OR 0.03 95% CI 0.01–0.98) were found as independent predictors of mortality. Conclusion. In high-risk PE, admission APACHE II score and need for invasive mechanical ventilation may predict death in ICU. Thrombolytic therapy seems to be beneficial in these patients.http://dx.doi.org/10.1155/2016/2432808 |
| spellingShingle | Begüm Ergan Recai Ergün Taner Çalışkan Kutlay Aydın Murat Emre Tokur Yusuf Savran Uğur Koca Bilgin Cömert Necati Gökmen Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU Canadian Respiratory Journal |
| title | Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU |
| title_full | Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU |
| title_fullStr | Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU |
| title_full_unstemmed | Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU |
| title_short | Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU |
| title_sort | mortality related risk factors in high risk pulmonary embolism in the icu |
| url | http://dx.doi.org/10.1155/2016/2432808 |
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