Glutaminase inhibition ameliorates cancer-associated fibroblast lipid support of pancreatic cancer cell growth

Glutaminase inhibition ameliorates cancer-associated fibroblast lipid support of pancreatic cancer cell growth

Abstract Background Lipid homeostasis is critical for pancreatic adenocarcinoma (PDAC) cell survival under hypoxic and nutrient-deprived conditions. Hypoxia inhibits unsaturated lipid biosynthesis, compelling cancer cells to depend on exogenous unsaturated lipids to counteract saturated lipid-induce...

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Bibliographic Details
Main Authors:	Xu Han, Laura C. Kim, Nicholas P. Lesner, Xuanyan Cai, Tran Ngoc Van Le, M. Celeste Simon
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	Cancer & Metabolism
Online Access:	https://doi.org/10.1186/s40170-025-00389-z
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