Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis
Periodontitis is one of the diabetic complications due to its high morbidity and severity in patients with diabetes. The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional. Here, we evaluated the impac...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8843310 |
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| author | Noritaka Sawada Kei Adachi Nobuhisa Nakamura Megumi Miyabe Mizuho Ito Shuichiro Kobayashi Shin-ichi Miyajima Yuki Suzuki Takeshi Kikuchi Makoto Mizutani Taku Toriumi Masaki Honda Akio Mitani Tatsuaki Matsubara Keiko Naruse |
| author_facet | Noritaka Sawada Kei Adachi Nobuhisa Nakamura Megumi Miyabe Mizuho Ito Shuichiro Kobayashi Shin-ichi Miyajima Yuki Suzuki Takeshi Kikuchi Makoto Mizutani Taku Toriumi Masaki Honda Akio Mitani Tatsuaki Matsubara Keiko Naruse |
| author_sort | Noritaka Sawada |
| collection | DOAJ |
| description | Periodontitis is one of the diabetic complications due to its high morbidity and severity in patients with diabetes. The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional. Here, we evaluated the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on the amelioration of periodontitis. Five-wk-old Male Sprague–Dawley (SD) rats (n=30) were divided into 3 groups: normal, periodontitis, and periodontitis with liraglutide treatment groups. Periodontitis was induced by ligature around the maxillary second molar in SD rats. Half of the rats were administered liraglutide for 2 weeks. Periodontitis was evaluated by histological staining, gene expressions of inflammatory cytokines in gingiva, and microcomputed tomography. Periodontitis increased inflammatory cell infiltration, macrophage accumulation, and gene expressions of tumor necrosis factor-α and inducible nitric oxide synthase in the gingiva, all of which were ameliorated by liraglutide. Liraglutide decreased M1 macrophages but did not affect M2 macrophages in periodontitis. Moreover, ligature-induced alveolar bone resorption was ameliorated by liraglutide. Liraglutide treatment also reduced osteoclasts on the alveolar bone surface. These results highlight the beyond glucose-lowering effects of liraglutide on the treatment of periodontitis. |
| format | Article |
| id | doaj-art-c6cfd4fd1cbe4a96a59e36a36c087bb5 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c6cfd4fd1cbe4a96a59e36a36c087bb52025-02-03T05:52:26ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/88433108843310Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of PeriodontitisNoritaka Sawada0Kei Adachi1Nobuhisa Nakamura2Megumi Miyabe3Mizuho Ito4Shuichiro Kobayashi5Shin-ichi Miyajima6Yuki Suzuki7Takeshi Kikuchi8Makoto Mizutani9Taku Toriumi10Masaki Honda11Akio Mitani12Tatsuaki Matsubara13Keiko Naruse14Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Oral Anatomy, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Oral Anatomy, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Oral Anatomy, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, JapanDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, JapanPeriodontitis is one of the diabetic complications due to its high morbidity and severity in patients with diabetes. The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional. Here, we evaluated the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on the amelioration of periodontitis. Five-wk-old Male Sprague–Dawley (SD) rats (n=30) were divided into 3 groups: normal, periodontitis, and periodontitis with liraglutide treatment groups. Periodontitis was induced by ligature around the maxillary second molar in SD rats. Half of the rats were administered liraglutide for 2 weeks. Periodontitis was evaluated by histological staining, gene expressions of inflammatory cytokines in gingiva, and microcomputed tomography. Periodontitis increased inflammatory cell infiltration, macrophage accumulation, and gene expressions of tumor necrosis factor-α and inducible nitric oxide synthase in the gingiva, all of which were ameliorated by liraglutide. Liraglutide decreased M1 macrophages but did not affect M2 macrophages in periodontitis. Moreover, ligature-induced alveolar bone resorption was ameliorated by liraglutide. Liraglutide treatment also reduced osteoclasts on the alveolar bone surface. These results highlight the beyond glucose-lowering effects of liraglutide on the treatment of periodontitis.http://dx.doi.org/10.1155/2020/8843310 |
| spellingShingle | Noritaka Sawada Kei Adachi Nobuhisa Nakamura Megumi Miyabe Mizuho Ito Shuichiro Kobayashi Shin-ichi Miyajima Yuki Suzuki Takeshi Kikuchi Makoto Mizutani Taku Toriumi Masaki Honda Akio Mitani Tatsuaki Matsubara Keiko Naruse Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis Journal of Diabetes Research |
| title | Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis |
| title_full | Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis |
| title_fullStr | Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis |
| title_full_unstemmed | Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis |
| title_short | Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis |
| title_sort | glucagon like peptide 1 receptor agonist liraglutide ameliorates the development of periodontitis |
| url | http://dx.doi.org/10.1155/2020/8843310 |
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