A Cap-Optimized mRNA Encoding Multiepitope Antigen ESAT6 Induces Robust Cellular and Humoral Immune Responses Against <i>Mycobacterium tuberculosis</i>

A Cap-Optimized mRNA Encoding Multiepitope Antigen ESAT6 Induces Robust Cellular and Humoral Immune Responses Against <i>Mycobacterium tuberculosis</i>

<b>Background/Objectives.</b> Tuberculosis is a deadly bacterial disease and the second most common cause of death from monoinfectious diseases worldwide. Comprehensive measures taken by health authorities in various countries in recent decades have saved tens of millions of lives, but t...

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Bibliographic Details
Main Authors: Alena Kozlova, Ildus Pateev, Galina Shepelkova, Olga Vasileva, Natalia Zakharova, Vladimir Yeremeev, Roman Ivanov, Vasiliy Reshetnikov
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
RNA vaccine
cap analog
tuberculosis
adaptive immunity
protective immunity
Online Access:https://www.mdpi.com/2076-393X/12/11/1267
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