ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
Abstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/487 |
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| author | U. V. Kolobovnikova O. I. Urazova V. V. Novitsky L. S. Litvinova O. V. Voronkova I. O. Naslednikova K. O. Mikheeva M. V. Ignatov |
| author_facet | U. V. Kolobovnikova O. I. Urazova V. V. Novitsky L. S. Litvinova O. V. Voronkova I. O. Naslednikova K. O. Mikheeva M. V. Ignatov |
| author_sort | U. V. Kolobovnikova |
| collection | DOAJ |
| description | Abstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is among key factors determining eosinophilic reactions of blood following infection with M. tuberculosis. Blood serum IL-5 concentrations proved to be significantly higher in patients with tuberculosis accompanied by eosinophilia. In these cases, eotaxin is a chemokine, which selectively acts upon eosinophilic cells. Its effects include prolonged persistence of eosinophils in bloodstream, along with initiation of eosinophil adherence to vascular endothelium, thus enabling subsequent migration of eosinophilic leukocytes to the foci of specific granulomatous inflammation. (Med. Immunol., 2011, vol. 13, N 2-3, pp 273-278) |
| format | Article |
| id | doaj-art-c6cd0a8be2da44c09fadde0c7a7ef8e5 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-c6cd0a8be2da44c09fadde0c7a7ef8e52025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01132-327327810.15789/1563-0625-2011-2-3-273-278484ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSISU. V. Kolobovnikova0O. I. Urazova1V. V. Novitsky2L. S. Litvinova3O. V. Voronkova4I. O. Naslednikova5K. O. Mikheeva6M. V. Ignatov7ГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскAbstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is among key factors determining eosinophilic reactions of blood following infection with M. tuberculosis. Blood serum IL-5 concentrations proved to be significantly higher in patients with tuberculosis accompanied by eosinophilia. In these cases, eotaxin is a chemokine, which selectively acts upon eosinophilic cells. Its effects include prolonged persistence of eosinophils in bloodstream, along with initiation of eosinophil adherence to vascular endothelium, thus enabling subsequent migration of eosinophilic leukocytes to the foci of specific granulomatous inflammation. (Med. Immunol., 2011, vol. 13, N 2-3, pp 273-278)https://www.mimmun.ru/mimmun/article/view/487lung tuberculosiseosinophiliacytokines |
| spellingShingle | U. V. Kolobovnikova O. I. Urazova V. V. Novitsky L. S. Litvinova O. V. Voronkova I. O. Naslednikova K. O. Mikheeva M. V. Ignatov ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS Медицинская иммунология lung tuberculosis eosinophilia cytokines |
| title | ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS |
| title_full | ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS |
| title_fullStr | ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS |
| title_full_unstemmed | ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS |
| title_short | ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS |
| title_sort | role of il 5 and eotaxin in development of blood eosinophilic reaction during pulmonary tuberculosis |
| topic | lung tuberculosis eosinophilia cytokines |
| url | https://www.mimmun.ru/mimmun/article/view/487 |
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