Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects
Breast cancer is a type of carcinoma with a high prevalence. The treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most com...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Differential Equations |
| Online Access: | http://dx.doi.org/10.1155/2021/3401639 |
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| author | M. Ivan Ariful Fathoni Fajar Adi-Kusumo Gunardi Gunardi Susanna Hilda Hutajulu |
| author_facet | M. Ivan Ariful Fathoni Fajar Adi-Kusumo Gunardi Gunardi Susanna Hilda Hutajulu |
| author_sort | M. Ivan Ariful Fathoni |
| collection | DOAJ |
| description | Breast cancer is a type of carcinoma with a high prevalence. The treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. The model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case. |
| format | Article |
| id | doaj-art-c6c818d27a6d40bfbb281c810ced4daf |
| institution | Kabale University |
| issn | 1687-9643 1687-9651 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Differential Equations |
| spelling | doaj-art-c6c818d27a6d40bfbb281c810ced4daf2025-02-03T01:27:19ZengWileyInternational Journal of Differential Equations1687-96431687-96512021-01-01202110.1155/2021/34016393401639Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy EffectsM. Ivan Ariful Fathoni0Fajar Adi-Kusumo1Gunardi Gunardi2Susanna Hilda Hutajulu3Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, IndonesiaBreast cancer is a type of carcinoma with a high prevalence. The treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. The model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case.http://dx.doi.org/10.1155/2021/3401639 |
| spellingShingle | M. Ivan Ariful Fathoni Fajar Adi-Kusumo Gunardi Gunardi Susanna Hilda Hutajulu Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects International Journal of Differential Equations |
| title | Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects |
| title_full | Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects |
| title_fullStr | Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects |
| title_full_unstemmed | Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects |
| title_short | Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects |
| title_sort | dynamics of a breast cancer model for neutropenia case due to chemotherapy effects |
| url | http://dx.doi.org/10.1155/2021/3401639 |
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