Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice
We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colit...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/23296 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548352521142272 |
|---|---|
| author | Alexandra Bukovská Štefan Cikoš Štefan Juhás Gabriela Il’ková Pavol Rehák Juraj Koppel |
| author_facet | Alexandra Bukovská Štefan Cikoš Štefan Juhás Gabriela Il’ková Pavol Rehák Juraj Koppel |
| author_sort | Alexandra Bukovská |
| collection | DOAJ |
| description | We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil
dietary administered at three concentrations (0.4% thyme and 0.2% oregano
oils; 0.2% thyme and 0.1%
oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis.
Treatment of colitic
animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines
IL-1β, IL-6, GM-CSF, and
TNFα, especially after application of the medium dose. The medium dose of the
essential oils significantly
lowered the amount of IL-1β and IL-6 proteins too. Moreover, administration of the medium dose decreased the
mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic
damage of the colonic
tissue. Our results indicate that combined treatment with appropriate concentrations of thyme
and oregano
essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate
TNBS-induced
colitis in mice. |
| format | Article |
| id | doaj-art-c6bfac08b8bf472892ff729d841ab061 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c6bfac08b8bf472892ff729d841ab0612025-02-03T06:14:16ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/2329623296Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in MiceAlexandra Bukovská0Štefan Cikoš1Štefan Juhás2Gabriela Il’ková3Pavol Rehák4Juraj Koppel5Institute of Animal Physiology, Slovak Academy of Sciences, Šoltésovej 4-6, Košice 04001, SlovakiaInstitute of Animal Physiology, Slovak Academy of Sciences, Šoltésovej 4-6, Košice 04001, SlovakiaInstitute of Animal Physiology, Slovak Academy of Sciences, Šoltésovej 4-6, Košice 04001, SlovakiaInstitute of Animal Physiology, Slovak Academy of Sciences, Šoltésovej 4-6, Košice 04001, SlovakiaInstitute of Animal Physiology, Slovak Academy of Sciences, Šoltésovej 4-6, Košice 04001, SlovakiaInstitute of Animal Physiology, Slovak Academy of Sciences, Šoltésovej 4-6, Košice 04001, SlovakiaWe examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, GM-CSF, and TNFα, especially after application of the medium dose. The medium dose of the essential oils significantly lowered the amount of IL-1β and IL-6 proteins too. Moreover, administration of the medium dose decreased the mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic damage of the colonic tissue. Our results indicate that combined treatment with appropriate concentrations of thyme and oregano essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate TNBS-induced colitis in mice.http://dx.doi.org/10.1155/2007/23296 |
| spellingShingle | Alexandra Bukovská Štefan Cikoš Štefan Juhás Gabriela Il’ková Pavol Rehák Juraj Koppel Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice Mediators of Inflammation |
| title | Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice |
| title_full | Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice |
| title_fullStr | Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice |
| title_full_unstemmed | Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice |
| title_short | Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice |
| title_sort | effects of a combination of thyme and oregano essential oils on tnbs induced colitis in mice |
| url | http://dx.doi.org/10.1155/2007/23296 |
| work_keys_str_mv | AT alexandrabukovska effectsofacombinationofthymeandoreganoessentialoilsontnbsinducedcolitisinmice AT stefancikos effectsofacombinationofthymeandoreganoessentialoilsontnbsinducedcolitisinmice AT stefanjuhas effectsofacombinationofthymeandoreganoessentialoilsontnbsinducedcolitisinmice AT gabrielailkova effectsofacombinationofthymeandoreganoessentialoilsontnbsinducedcolitisinmice AT pavolrehak effectsofacombinationofthymeandoreganoessentialoilsontnbsinducedcolitisinmice AT jurajkoppel effectsofacombinationofthymeandoreganoessentialoilsontnbsinducedcolitisinmice |