Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates
Abstract Hypothermia remains a leading contributing factor to neonatal mortality. This study reports testing of a thermoregulatory device—‘Thermal Jacket’ that includes a reusable chemical warming pad (CWP) and an insulating jacket designed for hypothermia management. The laboratory experiments were...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-96275-1 |
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| author | Anisuddin Ahmed Fariya Rahman Md. Mahinur Islam Mohammad Hridoy Patwary K. M. Tanvir Saifuddin Ahmed Abul Hussam Md. Mominul Islam Mats Målqvist Ahmed Ehsanur Rahman Shams El Arifeen Syed Moshfiqur Rahman |
| author_facet | Anisuddin Ahmed Fariya Rahman Md. Mahinur Islam Mohammad Hridoy Patwary K. M. Tanvir Saifuddin Ahmed Abul Hussam Md. Mominul Islam Mats Målqvist Ahmed Ehsanur Rahman Shams El Arifeen Syed Moshfiqur Rahman |
| author_sort | Anisuddin Ahmed |
| collection | DOAJ |
| description | Abstract Hypothermia remains a leading contributing factor to neonatal mortality. This study reports testing of a thermoregulatory device—‘Thermal Jacket’ that includes a reusable chemical warming pad (CWP) and an insulating jacket designed for hypothermia management. The laboratory experiments were conducted in two distinct phases between February’21 and June’22. In phase 1, a ternary composite of Sodium-Acetate-Trihydrate, Glycerol, Paraffin, and water contained in a high-density polyethylene-pouch named ‘CWP’ was finalised, and an insulating jacket was designed for targeted heat retention. In phase 2, the device’s efficacy was evaluated using a mannequin in a controlled setting. The sample size was 81 events. Welch’s t-test, ANOVA, and GEE were used to assess any significant differences between successful and failed events. Among 81 events, approximately 93% events of CWP and 98% events of insulating jacket successfully maintained temperature within 36–38°C for 120 minutes. Moreover, ambient temperature, reuse of CWPs, humidity did not have any significant effect on the success rate of the CWP and insulating jacket. Thermal Jacket had achieved and sustained the temperature range of 36–38°C for 2 hours. While this study used mannequin, clinical trial with preterm or low birthweight neonates is imperative to assess its effectiveness for thermal care management. |
| format | Article |
| id | doaj-art-c6bb4714586d4bfd8ca9f495593c95f4 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c6bb4714586d4bfd8ca9f495593c95f42025-08-20T03:06:50ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-96275-1Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonatesAnisuddin Ahmed0Fariya Rahman1Md. Mahinur Islam2Mohammad Hridoy Patwary3K. M. Tanvir4Saifuddin Ahmed5Abul Hussam6Md. Mominul Islam7Mats Målqvist8Ahmed Ehsanur Rahman9Shams El Arifeen10Syed Moshfiqur Rahman11Global Health and Migration Unit, Department of Women’s and Children’s Health, Uppsala UniversityMaternal and Child Health Division, International Centre for Diarrhoeal Disease ResearchDepartment of Chemistry and Biochemistry, The Florida State UniversityMaternal and Child Health Division, International Centre for Diarrhoeal Disease ResearchInstitute of Statistical Research and Training, University of DhakaDepartment of Population, Family and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins UniversityCenter for Clean Water and Sustainable Technologies, Department of Chemistry and Biochemistry, George Manson UniversityDepartment of Chemistry, University of DhakaCentre for Health and Sustainability, Department of Women’s and Children’s Health, Uppsala UniversityMaternal and Child Health Division, International Centre for Diarrhoeal Disease ResearchMaternal and Child Health Division, International Centre for Diarrhoeal Disease ResearchGlobal Health and Migration Unit, Department of Women’s and Children’s Health, Uppsala UniversityAbstract Hypothermia remains a leading contributing factor to neonatal mortality. This study reports testing of a thermoregulatory device—‘Thermal Jacket’ that includes a reusable chemical warming pad (CWP) and an insulating jacket designed for hypothermia management. The laboratory experiments were conducted in two distinct phases between February’21 and June’22. In phase 1, a ternary composite of Sodium-Acetate-Trihydrate, Glycerol, Paraffin, and water contained in a high-density polyethylene-pouch named ‘CWP’ was finalised, and an insulating jacket was designed for targeted heat retention. In phase 2, the device’s efficacy was evaluated using a mannequin in a controlled setting. The sample size was 81 events. Welch’s t-test, ANOVA, and GEE were used to assess any significant differences between successful and failed events. Among 81 events, approximately 93% events of CWP and 98% events of insulating jacket successfully maintained temperature within 36–38°C for 120 minutes. Moreover, ambient temperature, reuse of CWPs, humidity did not have any significant effect on the success rate of the CWP and insulating jacket. Thermal Jacket had achieved and sustained the temperature range of 36–38°C for 2 hours. While this study used mannequin, clinical trial with preterm or low birthweight neonates is imperative to assess its effectiveness for thermal care management.https://doi.org/10.1038/s41598-025-96275-1Sodium Acetate TrihydrateParaffinGlycerolHypothermia managementThermoregulatory deviceThermal Jacket |
| spellingShingle | Anisuddin Ahmed Fariya Rahman Md. Mahinur Islam Mohammad Hridoy Patwary K. M. Tanvir Saifuddin Ahmed Abul Hussam Md. Mominul Islam Mats Målqvist Ahmed Ehsanur Rahman Shams El Arifeen Syed Moshfiqur Rahman Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates Scientific Reports Sodium Acetate Trihydrate Paraffin Glycerol Hypothermia management Thermoregulatory device Thermal Jacket |
| title | Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates |
| title_full | Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates |
| title_fullStr | Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates |
| title_full_unstemmed | Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates |
| title_short | Testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates |
| title_sort | testing of a reusable chemical warming pad and an insulating jacket to manage hypothermia of preterm or low birthweight neonates |
| topic | Sodium Acetate Trihydrate Paraffin Glycerol Hypothermia management Thermoregulatory device Thermal Jacket |
| url | https://doi.org/10.1038/s41598-025-96275-1 |
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