3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning

3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning

Abstract Alzheimer’s Disease (AD) is a debilitating neurodegenerative disease that affects 47.5 million people worldwide. AD is characterised by the formation of plaques containing extracellular amyloid-β (Aβ) and neurofibrillary tangles composed of hyper-phosphorylated tau proteins (pTau). Aβ gradu...

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Bibliographic Details
Main Authors: Wissam B. Nassrallah, Hao Ran Li, Lyden Irani, Printha Wijesinghe, Peter William Hogg, Lucy Hui, Jean Oh, Ian R. Mackenzie, Veronica Hirsch-Reinshagen, Ging-Yuek Robin Hsiung, Wellington Pham, Sieun Lee, Joanne A. Matsubara
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Neuroretinal microglia
3-Dimensional morphology
Microglia morphology
Microglia count
Microglia size
Online Access:https://doi.org/10.1186/s40478-024-01898-6
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