Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer
Cervical cancer, ranking as the fourth most common cancer in women globally, is closely linked to chronic inflammation resulting from persistent human papillomavirus (HPV) infection. Chronic inflammation mediated by cyclooxygenase (COX) has been identified as a factor in cancer onset and progression...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004359 |
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| author | Xun Kan Zhenhuan Zhou Lianlian Liu Reziwanguli Aiskikaer Yinggang Zou |
| author_facet | Xun Kan Zhenhuan Zhou Lianlian Liu Reziwanguli Aiskikaer Yinggang Zou |
| author_sort | Xun Kan |
| collection | DOAJ |
| description | Cervical cancer, ranking as the fourth most common cancer in women globally, is closely linked to chronic inflammation resulting from persistent human papillomavirus (HPV) infection. Chronic inflammation mediated by cyclooxygenase (COX) has been identified as a factor in cancer onset and progression, with HPV oncoproteins E6 and E7 inducing COX activation. Nonsteroidal anti-inflammatory drugs (NSAIDs) have demonstrated the capability to significantly inhibit COX activity, playing a crucial preventive and therapeutic role in various tumors. This paper explores the therapeutic value and potential clinical applications of NSAIDs in cervical cancer by examining the mechanistic interactions between HPV and COX and the carcinogenic effects of COX in cervical cancer. |
| format | Article |
| id | doaj-art-c6a3732489014daf9cb4239d9c05fdbb |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-c6a3732489014daf9cb4239d9c05fdbb2025-01-26T05:04:15ZengElsevierHeliyon2405-84402025-02-01113e42055Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancerXun Kan0Zhenhuan Zhou1Lianlian Liu2Reziwanguli Aiskikaer3Yinggang Zou4Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaReproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaReproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaReproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaCorresponding author. 1. Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China.; Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaCervical cancer, ranking as the fourth most common cancer in women globally, is closely linked to chronic inflammation resulting from persistent human papillomavirus (HPV) infection. Chronic inflammation mediated by cyclooxygenase (COX) has been identified as a factor in cancer onset and progression, with HPV oncoproteins E6 and E7 inducing COX activation. Nonsteroidal anti-inflammatory drugs (NSAIDs) have demonstrated the capability to significantly inhibit COX activity, playing a crucial preventive and therapeutic role in various tumors. This paper explores the therapeutic value and potential clinical applications of NSAIDs in cervical cancer by examining the mechanistic interactions between HPV and COX and the carcinogenic effects of COX in cervical cancer.http://www.sciencedirect.com/science/article/pii/S2405844025004359Cervical cancerHPVNSAIDsChronic inflammationPrevention and treatment |
| spellingShingle | Xun Kan Zhenhuan Zhou Lianlian Liu Reziwanguli Aiskikaer Yinggang Zou Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer Heliyon Cervical cancer HPV NSAIDs Chronic inflammation Prevention and treatment |
| title | Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer |
| title_full | Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer |
| title_fullStr | Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer |
| title_full_unstemmed | Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer |
| title_short | Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer |
| title_sort | significance of non steroidal anti inflammatory drugs in the prevention and treatment of cervical cancer |
| topic | Cervical cancer HPV NSAIDs Chronic inflammation Prevention and treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004359 |
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