A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats
Cholestasis causes liver cirrhosis due to chronic total obstruction, in which accumulated bile acids induce liver inflammation and fibrosis. Inflammatory conditions are associated with hypoalbuminemia, and changes in albumin levels indicate the patient's clinical condition. Allium sativum h...
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Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
2025-03-01
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| Series: | Journal of Advanced Biotechnology and Experimental Therapeutics |
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| Online Access: | https://www.bsmiab.org/jabet/?mno=216646 |
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| author | Pratama Nurmalik Adhuri Neni Susilaningsih Sigit Adi Prasetyo Nani Maharani Trilaksana Nugroho |
| author_facet | Pratama Nurmalik Adhuri Neni Susilaningsih Sigit Adi Prasetyo Nani Maharani Trilaksana Nugroho |
| author_sort | Pratama Nurmalik Adhuri |
| collection | DOAJ |
| description | Cholestasis causes liver cirrhosis due to chronic total obstruction, in which accumulated bile acids induce liver inflammation and fibrosis. Inflammatory conditions are associated with hypoalbuminemia, and changes in albumin levels indicate the patient's clinical condition. Allium sativum has anti-inflammatory, antioxidant, and antifibrotic effects against various diseases. Further, ursodeoxycholic acid (UDCA) is one of the few available therapies for cirrhosis. Thus, this study aimed to assess the combination of A. sativum and UDCA as standard therapy in preventing liver cirrhosis and cholestasis. The current study was carried out with 35 male Sprague Dawley rats, which were randomly assigned into healthy, negative, and positive control groups, and three treatments of UDCA and graded doses of A. sativum extract. Biliary duct ligation was used for inducing cholestasis, and the treatment was given for 21 days. Liver cirrhosis was assessed based on Laennec grade by histopathological examination. Albumin levels are measured by examining blood serum. The combination of UDCA and A. sativum extract significantly reduced the degree of liver fibrosis and increased albumin levels in mice with cholestasis (p [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 192-199] |
| format | Article |
| id | doaj-art-c69bf841ef3d42cc806c480642985e4b |
| institution | Kabale University |
| issn | 2616-4760 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology |
| record_format | Article |
| series | Journal of Advanced Biotechnology and Experimental Therapeutics |
| spelling | doaj-art-c69bf841ef3d42cc806c480642985e4b2025-01-30T13:01:09ZengBangladesh Society for Microbiology, Immunology, and Advanced BiotechnologyJournal of Advanced Biotechnology and Experimental Therapeutics2616-47602025-03-018119219910.5455/jabet.2025.16216646A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic ratsPratama Nurmalik Adhuri0Neni Susilaningsih1Sigit Adi Prasetyo2Nani Maharani3Trilaksana Nugroho4Biomedical Science Postgraduate Program, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Department of Histology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Department of Digestive Surgery, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Department of Pharmacology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaCholestasis causes liver cirrhosis due to chronic total obstruction, in which accumulated bile acids induce liver inflammation and fibrosis. Inflammatory conditions are associated with hypoalbuminemia, and changes in albumin levels indicate the patient's clinical condition. Allium sativum has anti-inflammatory, antioxidant, and antifibrotic effects against various diseases. Further, ursodeoxycholic acid (UDCA) is one of the few available therapies for cirrhosis. Thus, this study aimed to assess the combination of A. sativum and UDCA as standard therapy in preventing liver cirrhosis and cholestasis. The current study was carried out with 35 male Sprague Dawley rats, which were randomly assigned into healthy, negative, and positive control groups, and three treatments of UDCA and graded doses of A. sativum extract. Biliary duct ligation was used for inducing cholestasis, and the treatment was given for 21 days. Liver cirrhosis was assessed based on Laennec grade by histopathological examination. Albumin levels are measured by examining blood serum. The combination of UDCA and A. sativum extract significantly reduced the degree of liver fibrosis and increased albumin levels in mice with cholestasis (p [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 192-199]https://www.bsmiab.org/jabet/?mno=216646cholestasis; cirrhosis; udca; albumin; allium sativum |
| spellingShingle | Pratama Nurmalik Adhuri Neni Susilaningsih Sigit Adi Prasetyo Nani Maharani Trilaksana Nugroho A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats Journal of Advanced Biotechnology and Experimental Therapeutics cholestasis; cirrhosis; udca; albumin; allium sativum |
| title | A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats |
| title_full | A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats |
| title_fullStr | A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats |
| title_full_unstemmed | A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats |
| title_short | A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats |
| title_sort | combination of ursodeoxycholic acid and allium sativum prevents liver cirrhosis in cholestatic rats |
| topic | cholestasis; cirrhosis; udca; albumin; allium sativum |
| url | https://www.bsmiab.org/jabet/?mno=216646 |
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