In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis
The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/361419 |
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| author | Anna Poma Anna Maria Ragnelli Joaquin de Lapuente David Ramos Miquel Borras Pierpaolo Aimola Mario Di Gioacchino Sandro Santucci Laura De Marzi |
| author_facet | Anna Poma Anna Maria Ragnelli Joaquin de Lapuente David Ramos Miquel Borras Pierpaolo Aimola Mario Di Gioacchino Sandro Santucci Laura De Marzi |
| author_sort | Anna Poma |
| collection | DOAJ |
| description | The attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations. TEM analysis showed the presence of NPs in alveolar macrophages. Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation). |
| format | Article |
| id | doaj-art-c696b6848ef04a89931b238bed15b090 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c696b6848ef04a89931b238bed15b0902025-02-03T06:44:27ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/361419361419In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM AnalysisAnna Poma0Anna Maria Ragnelli1Joaquin de Lapuente2David Ramos3Miquel Borras4Pierpaolo Aimola5Mario Di Gioacchino6Sandro Santucci7Laura De Marzi8Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyUnitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, SpainUnitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, SpainUnitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, SpainDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyImmunotoxicology and Allergy Unit, Ageing Research Center, University Foundation, Department of Medicine and Science of Ageing, University “D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Physical and Chemical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyThe attention on CeO2-NPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations. TEM analysis showed the presence of NPs in alveolar macrophages. Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation).http://dx.doi.org/10.1155/2014/361419 |
| spellingShingle | Anna Poma Anna Maria Ragnelli Joaquin de Lapuente David Ramos Miquel Borras Pierpaolo Aimola Mario Di Gioacchino Sandro Santucci Laura De Marzi In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis Journal of Immunology Research |
| title | In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis |
| title_full | In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis |
| title_fullStr | In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis |
| title_full_unstemmed | In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis |
| title_short | In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis |
| title_sort | in vivo inflammatory effects of ceria nanoparticles on cd 1 mouse evaluation by hematological histological and tem analysis |
| url | http://dx.doi.org/10.1155/2014/361419 |
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