The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options
Intracerebral hemorrhage (ICH) is a non traumatic hemorrhage that occurs in a certain part of the brain. It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1541230/full |
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| author | Jiayong Yao Xiaohong Dai Xueping Yv Lei Zheng Jia Zheng Binglin Kuang Wei Teng Weiwei Yu Mingyue Li Hongtao Cao Wei Zou Wei Zou |
| author_facet | Jiayong Yao Xiaohong Dai Xueping Yv Lei Zheng Jia Zheng Binglin Kuang Wei Teng Weiwei Yu Mingyue Li Hongtao Cao Wei Zou Wei Zou |
| author_sort | Jiayong Yao |
| collection | DOAJ |
| description | Intracerebral hemorrhage (ICH) is a non traumatic hemorrhage that occurs in a certain part of the brain. It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, we aim to determine how changes in oxidative stress biomarkers indicate the damage degree of cerebral hemorrhage, and to explore and summarize potential treatments or interventions. We found that patients with cerebral hemorrhage are characterized by increased levels of oxidative stress markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase and protein hydroxyl. Therefore, the changes of oxidative stress caused by ICH on these markers can be used to evaluate and diagnose ICH, predict its prognosis, and guide preventive treatment to turn to antioxidant based treatment as a new treatment alternative. |
| format | Article |
| id | doaj-art-c6965b6b2d2b4aff8efd8ae6049357ed |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-c6965b6b2d2b4aff8efd8ae6049357ed2025-02-04T05:27:57ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-02-011210.3389/fmolb.2025.15412301541230The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment optionsJiayong Yao0Xiaohong Dai1Xueping Yv2Lei Zheng3Jia Zheng4Binglin Kuang5Wei Teng6Weiwei Yu7Mingyue Li8Hongtao Cao9Wei Zou10Wei Zou11First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaKey Laboratory of Clinical Molecular Biology of Integrated Traditional Chinese and Western Medicine in Heilongjiang Province, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaKey Laboratory of Clinical Molecular Biology of Integrated Traditional Chinese and Western Medicine in Heilongjiang Province, Harbin, Heilongjiang, ChinaIntracerebral hemorrhage (ICH) is a non traumatic hemorrhage that occurs in a certain part of the brain. It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, we aim to determine how changes in oxidative stress biomarkers indicate the damage degree of cerebral hemorrhage, and to explore and summarize potential treatments or interventions. We found that patients with cerebral hemorrhage are characterized by increased levels of oxidative stress markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase and protein hydroxyl. Therefore, the changes of oxidative stress caused by ICH on these markers can be used to evaluate and diagnose ICH, predict its prognosis, and guide preventive treatment to turn to antioxidant based treatment as a new treatment alternative.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1541230/fulloxidative stressintracerebral hemorrhageoxidative stress biomarkersantioxidant therapystroke |
| spellingShingle | Jiayong Yao Xiaohong Dai Xueping Yv Lei Zheng Jia Zheng Binglin Kuang Wei Teng Weiwei Yu Mingyue Li Hongtao Cao Wei Zou Wei Zou The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options Frontiers in Molecular Biosciences oxidative stress intracerebral hemorrhage oxidative stress biomarkers antioxidant therapy stroke |
| title | The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options |
| title_full | The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options |
| title_fullStr | The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options |
| title_full_unstemmed | The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options |
| title_short | The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options |
| title_sort | role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options |
| topic | oxidative stress intracerebral hemorrhage oxidative stress biomarkers antioxidant therapy stroke |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1541230/full |
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