α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume
Xylariaceae sp. QGS 01, an endophytic fungus isolated from the stem of Quercus gilva Blume showed high α-glucosidase inhibitory activity. α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs. The α-glucosidase inhi...
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| Language: | English |
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Tsinghua University Press
2017-06-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453017300034 |
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| author | Anastasia Wheni Indrianingsih Sanro Tachibana |
| author_facet | Anastasia Wheni Indrianingsih Sanro Tachibana |
| author_sort | Anastasia Wheni Indrianingsih |
| collection | DOAJ |
| description | Xylariaceae sp. QGS 01, an endophytic fungus isolated from the stem of Quercus gilva Blume showed high α-glucosidase inhibitory activity. α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs. The α-glucosidase inhibitor constituents were isolated from the ethyl acetate extract of the mycellium of endophytic fungi Xylariaceae sp. QGS 01 using a bioassay-guided fractionation technique. Further separation and purification of the active fraction led to the isolation of constituents with strong inhibitory activities against α-glucosidase: 8-hydroxy-6,7-dimethoxy-3-methylisocoumarine (1) with inhibitory concentration (IC50) values against α-glucosidase from Saccharomyces cerevisiae of 41.75 μg/mL, while quercetin as the standard had an IC50 value of 4.80 μg/mL. The results of the present study showed that the endophytic fungus Xylariaceae sp. QGS 01 is potentially a rich source of antidiabetic medicine. |
| format | Article |
| id | doaj-art-c68a543b4bbb4763882d4b0f3de844e3 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-c68a543b4bbb4763882d4b0f3de844e32025-02-02T23:24:42ZengTsinghua University PressFood Science and Human Wellness2213-45302017-06-0162889510.1016/j.fshw.2017.05.001α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva BlumeAnastasia Wheni Indrianingsih0Sanro Tachibana1Research Unit for Natural Products Technology, Indonesian Institute of Sciences, Gading, Playen, Gunungkidul, Yogyakarta, 55581, IndonesiaDepartment of Applied Biosciences, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi Matsuyama, Ehime 790-8566, JapanXylariaceae sp. QGS 01, an endophytic fungus isolated from the stem of Quercus gilva Blume showed high α-glucosidase inhibitory activity. α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs. The α-glucosidase inhibitor constituents were isolated from the ethyl acetate extract of the mycellium of endophytic fungi Xylariaceae sp. QGS 01 using a bioassay-guided fractionation technique. Further separation and purification of the active fraction led to the isolation of constituents with strong inhibitory activities against α-glucosidase: 8-hydroxy-6,7-dimethoxy-3-methylisocoumarine (1) with inhibitory concentration (IC50) values against α-glucosidase from Saccharomyces cerevisiae of 41.75 μg/mL, while quercetin as the standard had an IC50 value of 4.80 μg/mL. The results of the present study showed that the endophytic fungus Xylariaceae sp. QGS 01 is potentially a rich source of antidiabetic medicine.http://www.sciencedirect.com/science/article/pii/S2213453017300034Endophytic fungiQuercus qilva Blumeα-Glucosidase inhibitory activityXylariaceae sp.Isocoumarine derivative |
| spellingShingle | Anastasia Wheni Indrianingsih Sanro Tachibana α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume Food Science and Human Wellness Endophytic fungi Quercus qilva Blume α-Glucosidase inhibitory activity Xylariaceae sp. Isocoumarine derivative |
| title | α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume |
| title_full | α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume |
| title_fullStr | α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume |
| title_full_unstemmed | α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume |
| title_short | α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume |
| title_sort | α glucosidase inhibitor produced by an endophytic fungus xylariaceae sp qgs 01 from quercus gilva blume |
| topic | Endophytic fungi Quercus qilva Blume α-Glucosidase inhibitory activity Xylariaceae sp. Isocoumarine derivative |
| url | http://www.sciencedirect.com/science/article/pii/S2213453017300034 |
| work_keys_str_mv | AT anastasiawheniindrianingsih aglucosidaseinhibitorproducedbyanendophyticfungusxylariaceaespqgs01fromquercusgilvablume AT sanrotachibana aglucosidaseinhibitorproducedbyanendophyticfungusxylariaceaespqgs01fromquercusgilvablume |