Glioblastoma Multiforme Stem Cells
Glioblastoma multiforme (GBM) is an aggressive, malignant, and lethal brain tumor, resistant to all current forms of treatment. The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screenin...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.42 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554662916521984 |
|---|---|
| author | Irena Dimov Deasanka Tasic-Dimov Irena Conic Vladisav Stefanovic |
| author_facet | Irena Dimov Deasanka Tasic-Dimov Irena Conic Vladisav Stefanovic |
| author_sort | Irena Dimov |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is an aggressive, malignant, and lethal brain tumor, resistant to all current forms of treatment. The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screening techniques has provided cause for optimism related to the development of more reliable therapies primarily targeting GBM stem cells (GBMSCs). There are promising mounting data on providing new molecular targets and predictive markers of response, leading to more effective therapies of GBM, guided by patient-specific genetic and epigenetic profiling. However, the achievement of efficient GBMSC targeting also requires an adequate understanding of the unique microenvironment, and the relationship with the immune system in the central nervous system (CNS) and CNS tumors. The endogenous immune regulation is likely to limit or abrogate the efficacy of the host's immune response, as well as the developed immunotherapeutic strategies at present. Therefore, a comprehensive understanding of the mechanisms underlying the GBM-induced immunosuppression is indispensable. This review presents a summary of the present knowledge both on GBMSCs and the GBM, and/or GBMSC-related mechanisms of developing both local and systemic immunosuppression, of which an understanding may lead to the development of the novel and effective therapeutic strategies. |
| format | Article |
| id | doaj-art-c689714024f2415b8bdeda679fa86868 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c689714024f2415b8bdeda679fa868682025-02-03T05:50:58ZengWileyThe Scientific World Journal1537-744X2011-01-011193095810.1100/tsw.2011.42Glioblastoma Multiforme Stem CellsIrena Dimov0Deasanka Tasic-Dimov1Irena Conic2Vladisav Stefanovic3University of Niš, School of Medicine, Niš, SerbiaUniversity of Niš, School of Medicine, Niš, SerbiaUniversity of Niš, School of Medicine, Niš, SerbiaUniversity of Niš, School of Medicine, Niš, SerbiaGlioblastoma multiforme (GBM) is an aggressive, malignant, and lethal brain tumor, resistant to all current forms of treatment. The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screening techniques has provided cause for optimism related to the development of more reliable therapies primarily targeting GBM stem cells (GBMSCs). There are promising mounting data on providing new molecular targets and predictive markers of response, leading to more effective therapies of GBM, guided by patient-specific genetic and epigenetic profiling. However, the achievement of efficient GBMSC targeting also requires an adequate understanding of the unique microenvironment, and the relationship with the immune system in the central nervous system (CNS) and CNS tumors. The endogenous immune regulation is likely to limit or abrogate the efficacy of the host's immune response, as well as the developed immunotherapeutic strategies at present. Therefore, a comprehensive understanding of the mechanisms underlying the GBM-induced immunosuppression is indispensable. This review presents a summary of the present knowledge both on GBMSCs and the GBM, and/or GBMSC-related mechanisms of developing both local and systemic immunosuppression, of which an understanding may lead to the development of the novel and effective therapeutic strategies.http://dx.doi.org/10.1100/tsw.2011.42 |
| spellingShingle | Irena Dimov Deasanka Tasic-Dimov Irena Conic Vladisav Stefanovic Glioblastoma Multiforme Stem Cells The Scientific World Journal |
| title | Glioblastoma Multiforme Stem Cells |
| title_full | Glioblastoma Multiforme Stem Cells |
| title_fullStr | Glioblastoma Multiforme Stem Cells |
| title_full_unstemmed | Glioblastoma Multiforme Stem Cells |
| title_short | Glioblastoma Multiforme Stem Cells |
| title_sort | glioblastoma multiforme stem cells |
| url | http://dx.doi.org/10.1100/tsw.2011.42 |
| work_keys_str_mv | AT irenadimov glioblastomamultiformestemcells AT deasankatasicdimov glioblastomamultiformestemcells AT irenaconic glioblastomamultiformestemcells AT vladisavstefanovic glioblastomamultiformestemcells |