Bone Marrow Stem Cell as a Potential Treatment for Diabetes
Diabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood glucose levels resulting from defects in insulin secretion and insulin action. The chronic hyperglycemia damages the eyes, kidneys, nerves, heart, and blood vessels. Curative therapies mainly include diet, insul...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/329596 |
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| _version_ | 1832558062632697856 |
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| author | Ming Li Susumu Ikehara |
| author_facet | Ming Li Susumu Ikehara |
| author_sort | Ming Li |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood glucose levels resulting from defects in insulin secretion and insulin action. The chronic hyperglycemia damages the eyes, kidneys, nerves, heart, and blood vessels. Curative therapies mainly include diet, insulin, and oral hypoglycemic agents. However, these therapies fail to maintain blood glucose levels in the normal range all the time. Although pancreas or islet-cell transplantation achieves better glucose control, a major obstacle is the shortage of donor organs. Recently, research has focused on stem cells which can be classified into embryonic stem cells (ESCs) and tissue stem cells (TSCs) to generate functional β cells. TSCs include the bone-marrow-, liver-, and pancreas-derived stem cells. In this review, we focus on treatment using bone marrow stem cells for type 1 and 2 DM. |
| format | Article |
| id | doaj-art-c6862a1c38664ce2ab7aad56d4e8cfa5 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c6862a1c38664ce2ab7aad56d4e8cfa52025-02-03T01:33:28ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/329596329596Bone Marrow Stem Cell as a Potential Treatment for DiabetesMing Li0Susumu Ikehara1Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570-8506, JapanDepartment of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570-8506, JapanDiabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood glucose levels resulting from defects in insulin secretion and insulin action. The chronic hyperglycemia damages the eyes, kidneys, nerves, heart, and blood vessels. Curative therapies mainly include diet, insulin, and oral hypoglycemic agents. However, these therapies fail to maintain blood glucose levels in the normal range all the time. Although pancreas or islet-cell transplantation achieves better glucose control, a major obstacle is the shortage of donor organs. Recently, research has focused on stem cells which can be classified into embryonic stem cells (ESCs) and tissue stem cells (TSCs) to generate functional β cells. TSCs include the bone-marrow-, liver-, and pancreas-derived stem cells. In this review, we focus on treatment using bone marrow stem cells for type 1 and 2 DM.http://dx.doi.org/10.1155/2013/329596 |
| spellingShingle | Ming Li Susumu Ikehara Bone Marrow Stem Cell as a Potential Treatment for Diabetes Journal of Diabetes Research |
| title | Bone Marrow Stem Cell as a Potential Treatment for Diabetes |
| title_full | Bone Marrow Stem Cell as a Potential Treatment for Diabetes |
| title_fullStr | Bone Marrow Stem Cell as a Potential Treatment for Diabetes |
| title_full_unstemmed | Bone Marrow Stem Cell as a Potential Treatment for Diabetes |
| title_short | Bone Marrow Stem Cell as a Potential Treatment for Diabetes |
| title_sort | bone marrow stem cell as a potential treatment for diabetes |
| url | http://dx.doi.org/10.1155/2013/329596 |
| work_keys_str_mv | AT mingli bonemarrowstemcellasapotentialtreatmentfordiabetes AT susumuikehara bonemarrowstemcellasapotentialtreatmentfordiabetes |