Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage
ABSTRACT: Purpose: This study aims to investigate factors associated with the development of biloma after Kasai operation, and to study the outcomes of treatment. Methods: A retrospective chart review was conducted on biliary atresia patients who underwent Kasai operation at Siriraj Hospital from 2...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Pediatric Surgery Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949711624000741 |
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| _version_ | 1832591797121974272 |
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| author | Niramol Tantemsapya Rattakan Jutiyon Mongkol Laohapensang |
| author_facet | Niramol Tantemsapya Rattakan Jutiyon Mongkol Laohapensang |
| author_sort | Niramol Tantemsapya |
| collection | DOAJ |
| description | ABSTRACT: Purpose: This study aims to investigate factors associated with the development of biloma after Kasai operation, and to study the outcomes of treatment. Methods: A retrospective chart review was conducted on biliary atresia patients who underwent Kasai operation at Siriraj Hospital from 2006 to 2021. The eligible 79 patients were divided into groups with biloma (n=13) and without biloma. Clinical and laboratory data at diagnosis and postoperation were compared. The treatment outcome of biloma was studied. Finally, the overall outcomes of portoenterostomy between both groups were analyzed. Results: Patients with biloma demonstrated a longer time to jaundice clearance (p=0.004), more frequent episodes of postoperative cholangitis (p=0.006), and higher levels of alkaline phosphatase (ALP) at 5 months post-operation (p=0.037). There was a significant decrease in bilirubin levels (p=0.028) and gamma-glutamyltransferase (GGT) (p=0.021) after biloma treatment. However, there was no significant difference in the overall outcomes of Kasai operation between the two groups. Conclusion: Biloma formation should be suspected in biliary atresia patients requiring longer duration to clear jaundice, having persistent ALP level and frequent episodes of cholangitis after the Kasai operation. Treatment of biloma improves liver function but it did not show a significant difference in the overall outcome of portoenterostomy. |
| format | Article |
| id | doaj-art-c68154ba50f646c59e1fff39472280bb |
| institution | Kabale University |
| issn | 2949-7116 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pediatric Surgery Open |
| spelling | doaj-art-c68154ba50f646c59e1fff39472280bb2025-01-22T05:44:37ZengElsevierJournal of Pediatric Surgery Open2949-71162025-01-019100189Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainageNiramol Tantemsapya0Rattakan Jutiyon1Mongkol Laohapensang2Corresponding author.; Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandABSTRACT: Purpose: This study aims to investigate factors associated with the development of biloma after Kasai operation, and to study the outcomes of treatment. Methods: A retrospective chart review was conducted on biliary atresia patients who underwent Kasai operation at Siriraj Hospital from 2006 to 2021. The eligible 79 patients were divided into groups with biloma (n=13) and without biloma. Clinical and laboratory data at diagnosis and postoperation were compared. The treatment outcome of biloma was studied. Finally, the overall outcomes of portoenterostomy between both groups were analyzed. Results: Patients with biloma demonstrated a longer time to jaundice clearance (p=0.004), more frequent episodes of postoperative cholangitis (p=0.006), and higher levels of alkaline phosphatase (ALP) at 5 months post-operation (p=0.037). There was a significant decrease in bilirubin levels (p=0.028) and gamma-glutamyltransferase (GGT) (p=0.021) after biloma treatment. However, there was no significant difference in the overall outcomes of Kasai operation between the two groups. Conclusion: Biloma formation should be suspected in biliary atresia patients requiring longer duration to clear jaundice, having persistent ALP level and frequent episodes of cholangitis after the Kasai operation. Treatment of biloma improves liver function but it did not show a significant difference in the overall outcome of portoenterostomy.http://www.sciencedirect.com/science/article/pii/S2949711624000741BilomaBile lakeIntrahepatic biliary cystsBiliary cystic dilatationBiliary atresiaPTBD |
| spellingShingle | Niramol Tantemsapya Rattakan Jutiyon Mongkol Laohapensang Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage Journal of Pediatric Surgery Open Biloma Bile lake Intrahepatic biliary cysts Biliary cystic dilatation Biliary atresia PTBD |
| title | Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage |
| title_full | Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage |
| title_fullStr | Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage |
| title_full_unstemmed | Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage |
| title_short | Factors associated with biloma formation in biliary atresia patients after Kasai operation and outcomes of percutaneous transhepatic biliary drainage |
| title_sort | factors associated with biloma formation in biliary atresia patients after kasai operation and outcomes of percutaneous transhepatic biliary drainage |
| topic | Biloma Bile lake Intrahepatic biliary cysts Biliary cystic dilatation Biliary atresia PTBD |
| url | http://www.sciencedirect.com/science/article/pii/S2949711624000741 |
| work_keys_str_mv | AT niramoltantemsapya factorsassociatedwithbilomaformationinbiliaryatresiapatientsafterkasaioperationandoutcomesofpercutaneoustranshepaticbiliarydrainage AT rattakanjutiyon factorsassociatedwithbilomaformationinbiliaryatresiapatientsafterkasaioperationandoutcomesofpercutaneoustranshepaticbiliarydrainage AT mongkollaohapensang factorsassociatedwithbilomaformationinbiliaryatresiapatientsafterkasaioperationandoutcomesofpercutaneoustranshepaticbiliarydrainage |