The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning
Objective. To investigate the effects of mung bean peptide and its’ complexes on promoting lead excretion and neuroprotection of zebrafish. Methods. The lead poisoning models of zebrafish were established by lead acetate solution; the models were treated with high and low concentrations (58.3 and 17...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2021/2851146 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556255094243328 |
|---|---|
| author | Wei Wei Shue Wang Xue-Jun Zhang Jiu-Xun Zhang Zheng-Wang Chen Jia-Ying Huang Ye-Wang Zhang |
| author_facet | Wei Wei Shue Wang Xue-Jun Zhang Jiu-Xun Zhang Zheng-Wang Chen Jia-Ying Huang Ye-Wang Zhang |
| author_sort | Wei Wei |
| collection | DOAJ |
| description | Objective. To investigate the effects of mung bean peptide and its’ complexes on promoting lead excretion and neuroprotection of zebrafish. Methods. The lead poisoning models of zebrafish were established by lead acetate solution; the models were treated with high and low concentrations (58.3 and 175 μg/mL) of mung bean peptides, with high, medium, and low concentrations (27.8, 83.3, and 250 μg/mL) of mung bean peptide complexes, separately. The effects of the mung bean peptide complexes on the lead content, axonal fluorescence intensity, and peripheral motor nerve length changes were identified in the zebrafish model, and the effects of mung bean peptide and its’ complexes on zebrafish's lead excretion, axonal protection rate, and peripheral movement promotion rate of nerve regeneration were calculated. Results. The effects of high concentration of mung bean peptide (175 μg/mL) in promoting lead excretion was 29% (p<0.05), and the effect of high concentration of mung bean peptide complexes (250 μg/mL) in promoting lead excretion was 30% (p<0.05). The other concentrations of mung bean peptide and its’ complex groups did not show a noticeable lead excretion effect. The protective effects of mung bean peptide at concentrations of 58.3 and 175 μg/mL against zebrafish axonal injury were 98% and 101% (p<0.01), and the peripheral nerve regeneration promotion effects were 29% (p>0.05) and 42% (p<0.05), respectively. The protective effects of mung bean peptide complexes at concentrations of 27.8, 83.3, and 250 μg/mL against zebrafish axonal injury were 85%, 78%, and 93% (p<0.01); peripheral nerve regeneration promotion rates were 46%, 50%, and 50% (p<0.05). Conclusion. The mung bean peptide and its’ complexes can effectively promote the discharge of lead in the zebrafish lead poisoning and have protective and regeneration effects on zebrafish nerves. |
| format | Article |
| id | doaj-art-c66ac5b65b184cef877e887a6c044980 |
| institution | Kabale University |
| issn | 0146-9428 1745-4557 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-c66ac5b65b184cef877e887a6c0449802025-02-03T05:45:57ZengWileyJournal of Food Quality0146-94281745-45572021-01-01202110.1155/2021/28511462851146The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead PoisoningWei Wei0Shue Wang1Xue-Jun Zhang2Jiu-Xun Zhang3Zheng-Wang Chen4Jia-Ying Huang5Ye-Wang Zhang6School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaSchool of Public Health, Shandong University, Jinan 250012, ChinaShandong Tianjiu Industry Group, Heze 274108, ChinaShandong Tianjiu Industry Group, Heze 274108, ChinaShandong Tianjiu Industry Group, Heze 274108, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaObjective. To investigate the effects of mung bean peptide and its’ complexes on promoting lead excretion and neuroprotection of zebrafish. Methods. The lead poisoning models of zebrafish were established by lead acetate solution; the models were treated with high and low concentrations (58.3 and 175 μg/mL) of mung bean peptides, with high, medium, and low concentrations (27.8, 83.3, and 250 μg/mL) of mung bean peptide complexes, separately. The effects of the mung bean peptide complexes on the lead content, axonal fluorescence intensity, and peripheral motor nerve length changes were identified in the zebrafish model, and the effects of mung bean peptide and its’ complexes on zebrafish's lead excretion, axonal protection rate, and peripheral movement promotion rate of nerve regeneration were calculated. Results. The effects of high concentration of mung bean peptide (175 μg/mL) in promoting lead excretion was 29% (p<0.05), and the effect of high concentration of mung bean peptide complexes (250 μg/mL) in promoting lead excretion was 30% (p<0.05). The other concentrations of mung bean peptide and its’ complex groups did not show a noticeable lead excretion effect. The protective effects of mung bean peptide at concentrations of 58.3 and 175 μg/mL against zebrafish axonal injury were 98% and 101% (p<0.01), and the peripheral nerve regeneration promotion effects were 29% (p>0.05) and 42% (p<0.05), respectively. The protective effects of mung bean peptide complexes at concentrations of 27.8, 83.3, and 250 μg/mL against zebrafish axonal injury were 85%, 78%, and 93% (p<0.01); peripheral nerve regeneration promotion rates were 46%, 50%, and 50% (p<0.05). Conclusion. The mung bean peptide and its’ complexes can effectively promote the discharge of lead in the zebrafish lead poisoning and have protective and regeneration effects on zebrafish nerves.http://dx.doi.org/10.1155/2021/2851146 |
| spellingShingle | Wei Wei Shue Wang Xue-Jun Zhang Jiu-Xun Zhang Zheng-Wang Chen Jia-Ying Huang Ye-Wang Zhang The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning Journal of Food Quality |
| title | The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning |
| title_full | The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning |
| title_fullStr | The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning |
| title_full_unstemmed | The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning |
| title_short | The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning |
| title_sort | effects of mung bean peptide and its complexes on the treatment of lead poisoning |
| url | http://dx.doi.org/10.1155/2021/2851146 |
| work_keys_str_mv | AT weiwei theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT shuewang theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT xuejunzhang theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT jiuxunzhang theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT zhengwangchen theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT jiayinghuang theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT yewangzhang theeffectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT weiwei effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT shuewang effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT xuejunzhang effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT jiuxunzhang effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT zhengwangchen effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT jiayinghuang effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning AT yewangzhang effectsofmungbeanpeptideanditscomplexesonthetreatmentofleadpoisoning |