Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis
Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. However, how to trigger the pyroptosis of tumor cells is a great challenge. Herein, a JNC nanoparticles (NPs) synchronous shared fluorescence imaging (FLI), oxygen-dependent reduction type Ⅰ photodynami...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S026412752500067X |
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| Summary: | Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. However, how to trigger the pyroptosis of tumor cells is a great challenge. Herein, a JNC nanoparticles (NPs) synchronous shared fluorescence imaging (FLI), oxygen-dependent reduction type Ⅰ photodynamic therapy (PDT) and high-efficiency photothermal therapy (PTT) were prepared. Furthermore, JNC NPs + Laser has excellent tumor killing ability in vitro and in vivo. The mechanism of cell death induced by JNC NPs + Laser was closely related to mitochondrial apoptosis and pyroptosis. Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. This finding provided a single component organic photosensitizer for tumor photodynamic/photothermal immunotherapy via apoptosis and pyroptosis. |
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| ISSN: | 0264-1275 |