Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review
IntroductionMiliary tuberculosis (MTB) is a potentially lethal form of tuberculosis that can occur in pregnant women, especially those who have conceived by in vitro fertilization (IVF).Case descriptionA 28-year-old, female patient, after IVF’s fourth attempt, at the end of the first trimester, deve...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1520644/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582262186573824 |
|---|---|
| author | Aleksandra Cvetkovic Ana Blanka Protic Jelena Jovanovic Tatjana Adzic Vukicevic Tatjana Adzic Vukicevic |
| author_facet | Aleksandra Cvetkovic Ana Blanka Protic Jelena Jovanovic Tatjana Adzic Vukicevic Tatjana Adzic Vukicevic |
| author_sort | Aleksandra Cvetkovic |
| collection | DOAJ |
| description | IntroductionMiliary tuberculosis (MTB) is a potentially lethal form of tuberculosis that can occur in pregnant women, especially those who have conceived by in vitro fertilization (IVF).Case descriptionA 28-year-old, female patient, after IVF’s fourth attempt, at the end of the first trimester, developed a dry cough, high fever, abdominal pain, and vaginal bleeding, which led to the pregnancy termination without resolution of systemic symptoms despite various antibiotics. Because of the appearance of headaches, brain nuclear magnetic resonance (NMR) was done, and diffuse nodular brain lesions were found, which were initially interpreted as metastatic cancer disease. Afterward, the miliary changes were discovered in various organ systems, and the presence of Mycobacterium tuberculosis was confirmed. The antituberculosis treatment was initiated with the standard antituberculosis regimen with excellent clinical response and resolution of miliary changes.ConclusionMiliary tuberculosis is more common in cases of pregnancies related to IVF. It should be taken into consideration as a possible risk for infertility in the presence of nonspecific symptoms. Screening methods for latent tuberculosis in IVF patients are needed even in a low-burden TB country. |
| format | Article |
| id | doaj-art-c663ad3b1b314032aecc99fbb5b01839 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-c663ad3b1b314032aecc99fbb5b018392025-01-30T05:10:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15206441520644Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature reviewAleksandra Cvetkovic0Ana Blanka Protic1Jelena Jovanovic2Tatjana Adzic Vukicevic3Tatjana Adzic Vukicevic4Clinic of Pulmonology, University Clinical Center of Serbia, Belgrade, SerbiaClinic of Pulmonology, University Clinical Center of Serbia, Belgrade, SerbiaClinic of Pulmonology, University Clinical Center of Serbia, Belgrade, SerbiaClinic of Pulmonology, University Clinical Center of Serbia, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaIntroductionMiliary tuberculosis (MTB) is a potentially lethal form of tuberculosis that can occur in pregnant women, especially those who have conceived by in vitro fertilization (IVF).Case descriptionA 28-year-old, female patient, after IVF’s fourth attempt, at the end of the first trimester, developed a dry cough, high fever, abdominal pain, and vaginal bleeding, which led to the pregnancy termination without resolution of systemic symptoms despite various antibiotics. Because of the appearance of headaches, brain nuclear magnetic resonance (NMR) was done, and diffuse nodular brain lesions were found, which were initially interpreted as metastatic cancer disease. Afterward, the miliary changes were discovered in various organ systems, and the presence of Mycobacterium tuberculosis was confirmed. The antituberculosis treatment was initiated with the standard antituberculosis regimen with excellent clinical response and resolution of miliary changes.ConclusionMiliary tuberculosis is more common in cases of pregnancies related to IVF. It should be taken into consideration as a possible risk for infertility in the presence of nonspecific symptoms. Screening methods for latent tuberculosis in IVF patients are needed even in a low-burden TB country.https://www.frontiersin.org/articles/10.3389/fmed.2025.1520644/fullmiliary tuberculosispregnancyin vitro fertilizationlatent tuberculosislow TB burden country |
| spellingShingle | Aleksandra Cvetkovic Ana Blanka Protic Jelena Jovanovic Tatjana Adzic Vukicevic Tatjana Adzic Vukicevic Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review Frontiers in Medicine miliary tuberculosis pregnancy in vitro fertilization latent tuberculosis low TB burden country |
| title | Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review |
| title_full | Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review |
| title_fullStr | Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review |
| title_full_unstemmed | Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review |
| title_short | Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review |
| title_sort | should miliary tuberculosis be considered as a possible cause of infertility in the new era a case report and literature review |
| topic | miliary tuberculosis pregnancy in vitro fertilization latent tuberculosis low TB burden country |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1520644/full |
| work_keys_str_mv | AT aleksandracvetkovic shouldmiliarytuberculosisbeconsideredasapossiblecauseofinfertilityintheneweraacasereportandliteraturereview AT anablankaprotic shouldmiliarytuberculosisbeconsideredasapossiblecauseofinfertilityintheneweraacasereportandliteraturereview AT jelenajovanovic shouldmiliarytuberculosisbeconsideredasapossiblecauseofinfertilityintheneweraacasereportandliteraturereview AT tatjanaadzicvukicevic shouldmiliarytuberculosisbeconsideredasapossiblecauseofinfertilityintheneweraacasereportandliteraturereview AT tatjanaadzicvukicevic shouldmiliarytuberculosisbeconsideredasapossiblecauseofinfertilityintheneweraacasereportandliteraturereview |