Novel oncolytic vaccinia virus armed with interleukin-27 is a potential therapeutic agent for the treatment of murine pancreatic cancer

Background Pancreatic cancer has a complex immunosuppressive tumor microenvironment (TME), which is highly resistant to conventional therapies and emerging cancer immunotherapies. Oncolytic viruses are multifaceted killers of malignant tumors, which can selectively infect, replicate in and lyse tumo...

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Main Authors: Bing Han, Yong Yang, Zhe Zhang, Pengju Wang, Yaohe Wang, Louisa S Chard Dunmall, Lihong Wang, Lijuan Chen, Ruimin Wang, Yanru Wang, Yangyang Jia, Guanghao Zhao, Wenyi Yan, Nicholas R Lemoine
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e010341.full
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