The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines
Background. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. Objectives. We examined the analgesic effect of LED therapy on incision pain and...
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Wiley
2017-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2017/4792489 |
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| author | Yuan-Yi Chia Chien-Cheng Liu Guan-Ming Feng Chia-Chih Alex Tseng Kuo-Chuan Hung Chih-Chieh Chen Ping-Heng Tan |
| author_facet | Yuan-Yi Chia Chien-Cheng Liu Guan-Ming Feng Chia-Chih Alex Tseng Kuo-Chuan Hung Chih-Chieh Chen Ping-Heng Tan |
| author_sort | Yuan-Yi Chia |
| collection | DOAJ |
| description | Background. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. Objectives. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α). Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only. The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05). Conclusions. LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin. |
| format | Article |
| id | doaj-art-c650024ea43d42d28dee5142a3ffe1bd |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-c650024ea43d42d28dee5142a3ffe1bd2025-02-03T05:50:20ZengWileyPain Research and Management1203-67651918-15232017-01-01201710.1155/2017/47924894792489The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory CytokinesYuan-Yi Chia0Chien-Cheng Liu1Guan-Ming Feng2Chia-Chih Alex Tseng3Kuo-Chuan Hung4Chih-Chieh Chen5Ping-Heng Tan6Department of Anesthesiology, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanDepartment of Plastic & Reconstructive Surgery, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanDepartment of Anesthesiology, National Cheng Kung University Medical College and Hospital, Tainan, TaiwanDepartment of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanDepartment of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanDepartment of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanBackground. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. Objectives. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α). Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only. The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05). Conclusions. LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.http://dx.doi.org/10.1155/2017/4792489 |
| spellingShingle | Yuan-Yi Chia Chien-Cheng Liu Guan-Ming Feng Chia-Chih Alex Tseng Kuo-Chuan Hung Chih-Chieh Chen Ping-Heng Tan The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines Pain Research and Management |
| title | The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines |
| title_full | The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines |
| title_fullStr | The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines |
| title_full_unstemmed | The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines |
| title_short | The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines |
| title_sort | antinociceptive effect of light emitting diode irradiation on incised wounds is correlated with changes in cyclooxygenase 2 activity prostaglandin e2 and proinflammatory cytokines |
| url | http://dx.doi.org/10.1155/2017/4792489 |
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