Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas
Neuroleptic malignant syndrome (NMS) is a life threatening medical state complicating the use of antipsychotic medications and other drugs that affect the dopaminergic system on administration or withdrawal. The condition was recognised nearly half a century ago, shortly after the discovery of antip...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2005/471260 |
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| _version_ | 1832555071662981120 |
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| author | Abebaw Fekadu Jonathan I. Bisson |
| author_facet | Abebaw Fekadu Jonathan I. Bisson |
| author_sort | Abebaw Fekadu |
| collection | DOAJ |
| description | Neuroleptic malignant syndrome (NMS) is a life threatening medical state complicating the use of antipsychotic medications and other drugs that affect the dopaminergic system on administration or withdrawal. The condition was recognised nearly half a century ago, shortly after the discovery of antipsychotic medications. However, there are still no systematic studies about NMS. There are no definitive guidelines on its treatment. Although early recognition is emphasised and usually possible, delayed diagnosis is not rare. We here report on a case of NMS complicated by renal failure, and possibly respiratory failure. The report underscores the seriousness of delayed diagnosis and puts forward a comprehensive management recommendation based on our experience and the existing literature. |
| format | Article |
| id | doaj-art-c64601181dfb4c9787ab4c0c5ced32d4 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c64601181dfb4c9787ab4c0c5ced32d42025-02-03T05:49:47ZengWileyBehavioural Neurology0953-41801875-85842005-01-0116191310.1155/2005/471260Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic DilemmasAbebaw Fekadu0Jonathan I. Bisson1St Ann’s Hospital, Poole, UKUniversity of Wales College of Medicine, Cardiff, UKNeuroleptic malignant syndrome (NMS) is a life threatening medical state complicating the use of antipsychotic medications and other drugs that affect the dopaminergic system on administration or withdrawal. The condition was recognised nearly half a century ago, shortly after the discovery of antipsychotic medications. However, there are still no systematic studies about NMS. There are no definitive guidelines on its treatment. Although early recognition is emphasised and usually possible, delayed diagnosis is not rare. We here report on a case of NMS complicated by renal failure, and possibly respiratory failure. The report underscores the seriousness of delayed diagnosis and puts forward a comprehensive management recommendation based on our experience and the existing literature.http://dx.doi.org/10.1155/2005/471260 |
| spellingShingle | Abebaw Fekadu Jonathan I. Bisson Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas Behavioural Neurology |
| title | Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas |
| title_full | Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas |
| title_fullStr | Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas |
| title_full_unstemmed | Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas |
| title_short | Neuroleptic Malignant Syndrome: Diagnostic and Therapeutic Dilemmas |
| title_sort | neuroleptic malignant syndrome diagnostic and therapeutic dilemmas |
| url | http://dx.doi.org/10.1155/2005/471260 |
| work_keys_str_mv | AT abebawfekadu neurolepticmalignantsyndromediagnosticandtherapeuticdilemmas AT jonathanibisson neurolepticmalignantsyndromediagnosticandtherapeuticdilemmas |